GPX4: old lessons, new features

被引：26
作者：
da Silva, Thamara Nishida Xavier [1 ]
Angeli, Jose Pedro Friedmann [1 ]
Ingold, Irina [2 ]
机构：
[1] Univ Wurzburg, Ctr Integrat & Translat Bioimaging, Rudolf Virchow Zentrum, Wurzburg, Germany
[2] Tech Univ Munich, Dept Med 3, Klinikum Rechts Isar, Munich, Germany
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2022年 / 50卷 / 03期
关键词：
HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION; CELL-DEATH; VITAMIN-E; EMBRYONIC LETHALITY; OXIDATIVE STRESS; NUCLEAR FORM; CANCER-CELLS; FERROPTOSIS; SELENIUM;
D O I：
10.1042/BST20220682
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
GPX4 is a selenocysteine-containing protein that plays an essential role in repairing per-oxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell death was essential for understanding the conditions that determine GPX4 dependency and ultimately to the process of lipid peroxidation. Since its discovery, ferroptosis has been gaining momentum as a promising target for yet-incurable diseases, including cancer and neurodegeneration. Given the current interest, in the present review, we provide new-comers in the field with an overview of the biology of GPX4 and cover some of its most recent discoveries.
引用
收藏
页码：1205 / 1213
页数：9
相关论文
共 76 条
  • [21] Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
    Hambright, William Sealy
    Fonseca, Rene Solano
    Chen, Liuji
    Na, Ren
    Ran, Qitao
    [J]. REDOX BIOLOGY, 2017, 12 : 8 - 17
  • [22] Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
    Hangauer, Matthew J.
    Viswanathan, Vasanthi S.
    Ryan, Matthew J.
    Bole, Dhruv
    Eaton, John K.
    Matov, Alexandre
    Galeas, Jacqueline
    Dhruv, Harshil D.
    Berens, Michael E.
    Schreiber, Stuart L.
    McCormick, Frank
    McManus, Michael T.
    [J]. NATURE, 2017, 551 (7679) : 247 - +
  • [23] Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene
    Imai, H
    Hirao, F
    Sakamoto, T
    Sekine, K
    Mizukura, Y
    Saito, M
    Kitamoto, T
    Hayasaka, M
    Hanaoka, K
    Nakagawa, Y
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 305 (02) : 278 - 286
  • [24] Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
    Ingold, Irina
    Berndt, Carsten
    Schmitt, Sabine
    Doll, Sebastian
    Poschmann, Gereon
    Buday, Katalin
    Roveri, Antonella
    Peng, Xiaoxiao
    Freitas, Florencio Porto
    Seibt, Tobias
    Mehr, Lisa
    Aichler, Michaela
    Walch, Axel
    Lamp, Daniel
    Jastroch, Martin
    Miyamoto, Sayuri
    Wurst, Wolfgang
    Ursini, Fulvio
    Amer, Elias S. J.
    Fradejas-Villar, Noelia
    Schweizer, Ulrich
    Zischka, Hans
    Angeli, Jose Pedro Friedmann
    Conrad, Marcus
    [J]. CELL, 2018, 172 (03) : 409 - +
  • [25] Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility
    Ingold, Irina
    Aichler, Michaela
    Yefremova, Elena
    Roveri, Antonella
    Buday, Katalin
    Doll, Sebastian
    Tasdemir, Adrianne
    Hoffard, Nils
    Wurst, Wolfgang
    Walch, Axel
    Ursini, Fulvio
    Angeli, Jose Pedro Friedmann
    Conrad, Marcus
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (23) : 14668 - 14678
  • [26] GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
    Kraft, Vanessa A. N.
    Bezjian, Carla T.
    Pfeiffer, Susanne
    Ringelstetter, Larissa
    Mueller, Constanze
    Zandkarimi, Fereshteh
    Merl-Pham, Juliane
    Bao, Xuanwen
    Anastasov, Natasa
    Koessl, Johanna
    Brandner, Stefanie
    Daniels, Jacob D.
    Schmitt-Kopplin, Philippe
    Hauck, Stefanie M.
    Stockwell, Brent R.
    Hadian, Kamyar
    Schick, Joel A.
    [J]. ACS CENTRAL SCIENCE, 2020, 6 (01) : 41 - 53
  • [27] The antioxidant requirement for plasma membrane repair in skeletal muscle
    Labazi, Mohamed
    McNeil, Anna K.
    Kurtz, Timothy
    Lee, Taylor C.
    Pegg, Ronald B.
    Angeli, Jose Pedro Friedmann
    Conrad, Marcus
    McNeil, Paul L.
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2015, 84 : 246 - 253
  • [28] Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions
    Liang, Hanyu
    Yoo, Si-Eun
    Na, Ren
    Walter, Christi A.
    Richardson, Arlan
    Ran, Qitao
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (45) : 30836 - 30844
  • [29] CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
    Liao, Peng
    Wang, Weimin
    Wang, Weichao
    Kryczek, Ilona
    Li, Xiong
    Bian, Yingjie
    Sell, Amanda
    Wei, Shuang
    Grove, Sara
    Johnson, Jeffrey K.
    Kennedy, Paul D.
    Gijon, Miguel
    Shah, Yatrik M.
    Zou, Weiping
    [J]. CANCER CELL, 2022, 40 (04) : 365 - +
  • [30] Synchronized renal tubular cell death involves ferroptosis
    Linkermann, Andreas
    Skouta, Rachid
    Himmerkus, Nina
    Mulay, Shrikant R.
    Dewitz, Christin
    De Zen, Federica
    Prokai, Agnes
    Zuchtriegel, Gabriele
    Krombach, Fritz
    Welz, Patrick-Simon
    Weinlich, Ricardo
    Vanden Berghe, Tom
    Vandenabeele, Peter
    Pasparakis, Manolis
    Bleich, Markus
    Weinberg, Joel M.
    Reichel, Christoph A.
    Braesen, Jan Hinrich
    Kunzendorf, Ulrich
    Anders, Hans-Joachim
    Stockwell, Brent R.
    Green, Douglas R.
    Krautwald, Stefan
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (47) : 16836 - 16841
12345678