GPX4: old lessons, new features

被引：33

作者：

da Silva, Thamara Nishida Xavier ^{[1
]}

Angeli, Jose Pedro Friedmann ^{[1
]}

Ingold, Irina ^{[2
]}

机构：

[1] Univ Wurzburg, Ctr Integrat & Translat Bioimaging, Rudolf Virchow Zentrum, Wurzburg, Germany

[2] Tech Univ Munich, Dept Med 3, Klinikum Rechts Isar, Munich, Germany

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2022年 / 50卷 / 03期

关键词：

HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION; CELL-DEATH; VITAMIN-E; EMBRYONIC LETHALITY; OXIDATIVE STRESS; NUCLEAR FORM; CANCER-CELLS; FERROPTOSIS; SELENIUM;

D O I：

10.1042/BST20220682

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GPX4 is a selenocysteine-containing protein that plays an essential role in repairing per-oxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell death was essential for understanding the conditions that determine GPX4 dependency and ultimately to the process of lipid peroxidation. Since its discovery, ferroptosis has been gaining momentum as a promising target for yet-incurable diseases, including cancer and neurodegeneration. Given the current interest, in the present review, we provide new-comers in the field with an overview of the biology of GPX4 and cover some of its most recent discoveries.

引用

页码：1205 / 1213

页数：9

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