Auditory gamma oscillations predict global symptomatic outcome in the early stages of psychosis: A longitudinal investigation

被引：33

作者：

Koshiyama, Daisuke ^{[1
]}

Kirihara, Kenji ^{[1
]}

Tada, Mariko ^{[1
,2
]}

Nagai, Tatsuya ^{[1
,3
]}

Fujioka, Mao ^{[1
]}

Ichikawa, Eriko ^{[1
]}

Ohta, Kazusa ^{[1
]}

Tani, Motoko ^{[1
]}

Tsuchiya, Maiko ^{[1
]}

Kanehara, Akiko ^{[1
]}

Morita, Kentaro ^{[1
]}

Sawada, Kingo ^{[1
]}

Matsuoka, Jun ^{[1
]}

Satomura, Yoshihiro ^{[1
]}

Koike, Shinsuke ^{[1
,2
,4
,5
]}

Suga, Motomu ^{[1
,6
]}

Araki, Tsuyoshi ^{[1
]}

Kasai, Kiyoto ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan

[2] Univ Tokyo, UTIAS, Int Res Ctr Neurointelligence WPI IRCN, Tokyo, Japan

[3] Kawamuro Mem Hosp, Dept Psychiat, Niigata, Japan

[4] UTIDAHM, Tokyo, Japan

[5] Univ Tokyo, Grad Sch Art & Sci, Ctr Evolutionary Cognit Sci, Tokyo, Japan

[6] Univ Tokyo, Grad Sch Med, Dept Rehabil, Tokyo, Japan

来源：

CLINICAL NEUROPHYSIOLOGY | 2018年 / 129卷 / 11期

关键词：

Gamma-band auditory steady-state response (ASSR); Ultra-high risk; Recent-onset schizophrenia; Longitudinal study; The global assessment of functioning (GAF); Symptomatic outcome; UNTREATED PSYCHOSIS; CHRONIC-SCHIZOPHRENIA; PARVALBUMIN NEURONS; JAPANESE VERSION; 1ST-EPISODE; DURATION; SYNCHRONIZATION; SCALE; ABNORMALITIES; METAANALYSIS;

D O I：

10.1016/j.clinph.2018.08.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: The gamma-band auditory steady-state response (ASSR) is thought to reflect the function of parvalbumin-positive gamma-aminobutyric acid (GABA)-ergic interneurons and may be a candidate biomarker in early psychosis. Although previous cross-sectional studies have shown that gamma-band ASSR is reduced in early psychosis, whether reduced gamma-band ASSR could be a predictor of the long-term prognosis remains unknown. Methods: In this longitudinal study, we investigated the association between gamma-band ASSR reduction and future global symptomatic or functional outcome in early psychosis. We measured 40-Hz ASSR in 34 patients with recent-onset schizophrenia (ROSZ), 28 ultra-high risk (UHR) individuals, and 30 healthy controls (HCs) at baseline. After 1-2 years, we evaluated the global assessment of functioning (GAF) in the ROSZ (N = 20) and UHR (N = 20) groups. Results: The 40-Hz ASSR was significantly reduced in the ROSZ and UHR groups. The attenuated 40-Hz ASSR was correlated with the future global symptomatic outcome in the ROSZ, but not in the UHR groups. Conclusions: A reduction in the gamma-band ASSR after the onset of psychosis may predict symptomatic outcomes in early psychosis. Significance: Gamma-band ASSR may be a potentially useful biomarker of the long-term prognosis in patients with recent-onset schizophrenia. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

引用

页码：2268 / 2275

页数：8

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