MOFs Extend the Lifetime of Pd(II) Catalyst for Room Temperature Alkenylation of Enamine-Like Arenes

被引：17

作者：

Cirujano, Francisco G. ^{[1
]}

Leo, Pedro ^{[2
]}

Vercammen, Jannick ^{[1
]}

Smolders, Simon ^{[1
]}

Orcajo, Gisela ^{[2
]}

De Vos, Dirk E. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Surface Chem & Catalysis, Celestijnenlaan 200F, B-3001 Leuven, Belgium

[2] Rey Juan Carlos Univ, ESCET, Dept Chem & Energy Technol, C Tulipan S-N, Mostoles 28933, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 20期

基金：

欧盟地平线“2020”;

关键词：

Indole; Uracil; Palladium; MOFs; Alkenylation; C-H ACTIVATION; METAL-ORGANIC FRAMEWORKS; CONTINUOUS-FLOW; MOLECULAR-OXYGEN; INDOLES; OXIDANT; FUNCTIONALIZATION; OXIDATION; DERIVATIVES; OLEFINATION;

D O I：

10.1002/adsc.201800817

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis of pharmaceutically relevant scaffolds, such as substituted indoles or uracils, through the alkenylation of the "enamine-like" aromatic C-H bond is performed at room temperature using catalytic amounts of Pd(OAc)(2) in the presence of redox active, stable and reusable metalorganic microporous frameworks. This is the first time that redox/acid active sites in the porous, nontoxic and earth abundant robust MOF-74 platform are used to avoid the fast deactivation of the cationic Pd species working under ambient conditions.

引用

页码：3872 / 3876

页数：5

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