Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients During Lamivudine Plus Dolutegravir Maintenance Therapy in Clinical Practice

被引：10

作者：

Borghetti, Alberto ^{[1
]}

Giacomelli, Andrea ^{[2
,3
]}

Borghi, Vanni ^{[4
]}

Ciccullo, Arturo ^{[5
]}

Dusina, Alex ^{[5
]}

Fabbiani, Massimiliano ^{[6
]}

Rusconi, Stefano ^{[2
,3
]}

Zazzi, Maurizio ^{[7
]}

Mussini, Cristina ^{[4
]}

Di Giambenedetto, Simona ^{[1
,5
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, UOC Malattie Infett, Rome, Italy

[2] Univ Milan, Luigi Sacco Dept Biomed & Clin Sci, Milan, Italy

[3] ASST Fatebenefratelli Sacco, Dept Infect Dis, Milan, Italy

[4] Azienda Osped Univ Modena, Clin Malattie Infett & Trop, Modena, Italy

[5] Univ Cattolica Sacro Cuore, Dipartimento Sicurezza & Bioet, Sez Malattie Infett, Rome, Italy

[6] Univ Hosp Siena, Dept Specialized & Internal Med, Trop & Infect Dis Unit, Siena, Italy

[7] Univ Siena, Dept Med Biotechnol, Siena, Italy

来源：

OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 07期

关键词：

dolutegravir; HIV; lamivudine; maintenance therapy; resistance-associated mutations;

D O I：

10.1093/ofid/ofab103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The TANGO trial demonstrated the efficacy of lamivudine plus dolutegravir in virologically suppressed patients without previous virological failures (VFs). In this dataset from clinical practice investigating the impact of past nucleoside reverse-transcriptase inhibitor resistance on this strategy, the combination of M184V/I plus at least 1 thymidine analog-associated mutation significantly increased the risk of VF.

引用

页数：5

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