Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents

被引：53

作者：

Hung, CC ^{[1
]}

Tsai, WJ ^{[1
]}

Kuo, LMY ^{[1
]}

Kuo, YH ^{[1
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 05期

关键词：

caffeic anilides; arachidonic acid; anti-platelet aggregation; anti-oxidation;

D O I：

10.1016/j.bmc.2004.11.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of amides of caffeic acid were synthesized and evaluated for their anti-platelet and anti-oxidative activities. N-(2-Bromo-phenyl)-3-(3,4-dihydroxy-phenyl)-acrylamide (12) and N-(3-Bromo-phenyl)-3-(3,4-dihydroxy-phenyl)-acrylamide (13) exhibited potent inhibitory activity (IC50 = 5.8 and 6.7 muM, respectively) against arachidonic acid-induced (AA) platelet aggregation, comparable with invalid caffeic acid. Most of the synthesized caffeic acid anifides exhibited the promising anti-platelet aggregation in AA-induced assay and anti-oxidative activities. This study also exhibited that caffeic anilides displayed more potent anti-oxidative activity in the radical scavenging activity assay than trolox and vitamin E. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1791 / 1797

页数：7

共 26 条

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ARDLIE NG, 1971, P SOC EXP BIOL MED, V136, P1021

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