Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

被引：9

作者：

Rosenblatt, Joshua ^{[1
]}

Leung, Annie ^{[4
,5
]}

Baneman, Emily ^{[1
]}

Fuller, Risa ^{[1
]}

Taimur, Sarah ^{[1
]}

Paniz-Mondolfi, Alberto E. ^{[2
]}

Malone, Adriana K. ^{[3
]}

Kirkman, Laura ^{[4
,5
]}

Jacobs, Samantha E. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Div Infect Dis, Dept Med, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Pathol Mol & Cell Based Med, Clin Microbiol Lab, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol Med Oncol, New York, NY 10029 USA

[4] Weill Cornell Med, Div Infect Dis, Dept Med, New York, NY USA

[5] Weill Cornell Med, Dept Microbiol & Immunol, New York, NY USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 09期

关键词：

Babesia microti; babesiosis; hematopoietic cell transplantation; immunocompromised host; tick-borne pathogens; ATOVAQUONE; RESISTANCE; RITUXIMAB;

D O I：

10.1093/ofid/ofab323

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.

引用

页数：6

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