Six-year contraceptive efficacy and continued safety of a levonorgestrel 52 mg intrauterine system

被引：15

作者：

Westhoff, Carolyn L. ^{[1
]}

Keder, Lisa M. ^{[2
]}

Gangestad, Angelina ^{[3
]}

Teal, Stephanie B. ^{[4
]}

Olariu, Andrea I. ^{[5
]}

Creinin, Mitchell D. ^{[6
]}

机构：

[1] Columbia Univ, Dept Obstet & Gynecol, New York, NY USA

[2] Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA

[3] Case Western Reserve Univ, Dept Reprod Biol, Cleveland, OH 44106 USA

[4] Univ Colorado, Dept Obstet & Gynecol, Aurora, CO USA

[5] Medicines360, San Francisco, CA USA

[6] Univ Calif Davis, Dept Obstet & Gynecol, Sacramento, CA 95817 USA

来源：

CONTRACEPTION | 2020年 / 101卷 / 03期

关键词：

Levonorgestrel; Intrauterine system; Liletta; Efficacy; Safety;

D O I：

10.1016/j.contraception.2019.10.010

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To assess 6-year contraceptive efficacy and safety of a levonorgestrel 52 mg intrauterine system (IUS). Study Design: We assessed pregnancy rates through 72 months in women aged 16-35 years at enrollment and safety in all participants (aged 16-45 years, n = 1751) in an ongoing 10-year phase-3 trial. Results: Over six years, nine pregnancies occurred (none in year 6) for a life-table pregnancy rate of 0.87 (95% CI 0.44-1.70). Adverse event rates remain low through 6 or more years of use. Two expulsions occurred in year 6. Conclusion: This levonorgestrel 52 mg IUS is a highly effective and safe contraceptive over 6 years of use. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：159 / 161

页数：3

共 5 条

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OBSTETRICS AND GYNECOLOGY, 2019, 133 (01) :63-70

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