Neurotoxicity of tryptophan metabolites

被引：32
作者：
Smith, A. J. [1 ]
Stone, T. W. [1 ]
Smith, R. A. [1 ]
机构：
[1] Univ Glasgow, Inst Biomed & Life Sci, Div Neurosci & Biomed Syst, Glasgow G12 8QQ, Lanark, Scotland
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷
关键词：
cerebellar granule neuron; 5-hydroxyanthranilic acid; 3-hydroxykynurenine kyriunenine; quinciinic acid; tryptophan metabolite;
D O I：
10.1042/BST0351287
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The metabolism of tryptophan by the kynurenine pathway leads to the production of several neurotoxic compounds, some of which have been associated with neurological disorders. Recent investigation of some relevant compounds in this pathway has provided further evidence of their neurotoxicity.
引用
收藏
页码：1287 / 1289
页数：3
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