Synthesis of 2,4-and 2,5-Disubstituted Oxazoles via Metal-Catalyzed Cross-Coupling Reactions

被引：20

作者：

Counceller, Carla M. ^{[1
]}

Eichman, Chad C. ^{[1
]}

Proust, Nicolas ^{[1
]}

Stambuli, James P. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Evans Labs, Columbus, OH 43210 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 01期

关键词：

cross-coupling; homogeneous catalysis; nickel; nitrogen heterocycles; palladium; POLYANGIUM SP; INHIBITOR; 2-LITHIOOXAZOLES; PHORBOXAZOLE; THIANGAZOLE; COMPLEXES; CONCISE; HIV-1; WATER;

D O I：

10.1002/adsc.201000668

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The rapid synthesis of 2,4- and 2,5-disubstituted oxazoles via metal-catalyzed cross-coupling reactions is reported. The 4- or 5-position of the corresponding 4- or 5-halogenated 2-butylthiooxazoles was successfully functionalized via Suzuki-Miyaura, Sonogashira and Stille cross-coupling reactions. The 2-position of the 2-butylthiooxazoles obtained was further coupled to various organozinc reagents through palladium-or nickel-mediated cross-coupling reactions.

引用

页码：79 / 83

页数：5

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