Synthesis of 2,4-and 2,5-Disubstituted Oxazoles via Metal-Catalyzed Cross-Coupling Reactions

被引：20
|
作者：
Counceller, Carla M. [1 ]
Eichman, Chad C. [1 ]
Proust, Nicolas [1 ]
Stambuli, James P. [1 ]
机构：
[1] Ohio State Univ, Dept Chem, Evans Labs, Columbus, OH 43210 USA
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 01期
关键词：
cross-coupling; homogeneous catalysis; nickel; nitrogen heterocycles; palladium; POLYANGIUM SP; INHIBITOR; 2-LITHIOOXAZOLES; PHORBOXAZOLE; THIANGAZOLE; COMPLEXES; CONCISE; HIV-1; WATER;
D O I：
10.1002/adsc.201000668
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The rapid synthesis of 2,4- and 2,5-disubstituted oxazoles via metal-catalyzed cross-coupling reactions is reported. The 4- or 5-position of the corresponding 4- or 5-halogenated 2-butylthiooxazoles was successfully functionalized via Suzuki-Miyaura, Sonogashira and Stille cross-coupling reactions. The 2-position of the 2-butylthiooxazoles obtained was further coupled to various organozinc reagents through palladium-or nickel-mediated cross-coupling reactions.
引用
收藏
页码：79 / 83
页数：5
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