Genistein: A Potent Anti-Breast Cancer Agent

被引：104

作者：

Bhat, Smitha S. ^{[1
]}

Prasad, Shashanka K. ^{[1
]}

Shivamallu, Chandan ^{[1
]}

Prasad, Kollur Shiva ^{[2
]}

Syed, Asad ^{[3
]}

Reddy, Pruthvish ^{[4
]}

Cull, Charley A. ^{[5
]}

Amachawadi, Raghavendra G. ^{[6
]}

机构：

[1] JSS Acad Higher Educ & Res, Dept Biotechnol & Bioinformat, Fac Life Sci, Mysuru 570015, Karnataka, India

[2] Amrita Vishwa Vidyapeetham, Amrita Sch Arts & Sci, Dept Sci, Mysuru Campus, Mysuru 570026, Karnataka, India

[3] King Saud Univ, Dept Bot & Microbiol, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia

[4] Acharya Inst Technol, Dept Biotechnol, Bengaluru 560107, Karnataka, India

[5] Midwest Vet Serv Inc, Oakland, NE 68045 USA

[6] Kansas State Univ, Dept Clin Sci, Coll Vet Med, Manhattan, KS 66506 USA

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2021年 / 43卷 / 03期

关键词：

genistein; apoptosis; breast cancer; cell cycle; estrogen receptor; SOY ISOFLAVONE GENISTEIN; FACTOR-KAPPA-B; CELL-CYCLE ARREST; MCF-7; CELLS; IN-VITRO; MITOCHONDRIAL FUNCTIONALITY; MAMMOSPHERE FORMATION; SIGNALING PATHWAY; GENE-EXPRESSION; MAMMARY-GLAND;

D O I：

10.3390/cimb43030106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide range of bioactives, it is being studied extensively for its tumoricidal effects. Investigations into mechanisms of the anti-cancer activity have revealed many pathways including induction of cell proliferation, suppression of tyrosine kinases, regulation of Hedgehog-Gli1 signaling, modulation of epigenetic activities, seizing of cell cycle and Akt and MEK signaling pathways, among others via which the cancer cell proliferation can be controlled. Notwithstanding, the observed activities have been time- and dose-dependent. In addition, genistein has also shown varying results in women depending on the physiological parameters, such as the early or post-menopausal states.

引用

收藏

页码：1502 / 1517

页数：16

相关论文

共 114 条

[81]

Seo HS, 2011, ANTICANCER RES, V31, P3301

[82] Genistein induces Ca2+-mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells [J].

Sergeev, IN .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 321 (02) :462-467

[83]

Shao ZM, 1998, CANCER RES, V58, P4851

[84] Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits [J].

Sharifi-Rad, Javad ;

Quispe, Cristina ;

Imran, Muhammad ;

Rauf, Abdur ;

Nadeem, Muhammad ;

Gondal, Tanweer Aslam ;

Ahmad, Bashir ;

Atif, Muhammad ;

Mubarak, Mohammad S. ;

Sytar, Oksana ;

Zhilina, Oxana Mihailovna ;

Garsiya, Ekaterina Robertovna ;

Smeriglio, Antonella ;

Trombetta, Domenico ;

Pons, Daniel Gabriel ;

Martorell, Miquel ;

Cardoso, Susana M. ;

Razis, Ahmad Faizal Abdull ;

Sunusi, Usman ;

Kamal, Ramla Muhammad ;

Rotariu, Lia Sanda ;

Butnariu, Monica ;

Docea, Anca Oana ;

Calina, Daniela .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021

[85] Synthesis, Characterization, and Antioxidant Activities of Genistein, Biochanin A, and Their Analogues [J].

Sherif, Salah Hamza ;

Gebreyohannes, BerihuTekluu .

JOURNAL OF CHEMISTRY, 2018, 2018

[86] The Effects of Soy Supplementation on Gene Expression in Breast Cancer: A Randomized Placebo-Controlled Study [J].

Shike, Moshe ;

Doane, Ashley S. ;

Russo, Lianne ;

Cabal, Rafael ;

Reis-Filho, Jorge S. ;

Gerald, William ;

Cody, Hiram ;

Khanin, Raya ;

Bromberg, Jacqueline ;

Norton, Larry .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (09)

[87] Sensitivity of TP53-Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity [J].

Shin, Sol-Bi ;

Woo, Sang-Uk ;

Chin, Young-Won ;

Jang, Young-Joo ;

Yim, Hyungshin .

JOURNAL OF CELLULAR PHYSIOLOGY, 2017, 232 (10) :2818-2828

[88] Multifunctional hybrid nanoconstructs facilitate intracellular localization of doxorubicin and genistein to enhance apoptotic and anti-angiogenic efficacy in breast adenocarcinoma [J].

Shukla, Ravi Prakash ;

Dewangan, Jayant ;

Urandur, Sandeep ;

Banala, Venkatesh Teja ;

Diwedi, Monika ;

Sharma, Shweta ;

Agrawal, Sristi ;

Rath, Srikanta Kumar ;

Trivedi, Ritu ;

Mishra, Prabhat Ranjan .

BIOMATERIALS SCIENCE, 2020, 8 (05) :1298-1315

[89] Quantitative Proteomics and Transcriptomics Addressing the Estrogen Receptor Subtype-mediated Effects in T47D Breast Cancer Cells Exposed to the Phytoestrogen Genistein [J].

Sotoca, Ana M. ;

Gelpke, Maarten D. Sollewijn ;

Boeren, Sjef ;

Stroem, Anders ;

Gustafsson, Jan-Ake ;

Murk, Albertinka J. ;

Rietjens, Ivonne M. C. M. ;

Vervoort, Jacques .

MOLECULAR & CELLULAR PROTEOMICS, 2011, 10 (01)

[90] Genistein and Cancer: Current Status, Challenges, and Future Directions [J].

Spagnuolo, Carmela ;

Russo, Gian Luigi ;

Orhan, Ilkay Erdogan ;

Habtemariam, Solomon ;

Daglia, Maria ;

Sureda, Antoni ;

Nabavi, Seyed Fazel ;

Devi, Kasi Pandima ;

Loizzo, Monica Rosa ;

Tundis, Rosa ;

Nabavi, Seyed Mohammad .

ADVANCES IN NUTRITION, 2015, 6 (04) :408-419

← 3 4 5 6 7 8 9 10 11 12 →