Fast recognition of single molecules based on single-event photon statistics

被引：14

作者：

Dong, Shuangli ^{[1
]}

Huang, Tao ^{[1
]}

Liu, Yuan ^{[1
]}

Wang, Jun ^{[1
]}

Zhang, Guofeng ^{[1
]}

Xiao, Liantuan ^{[1
]}

Jia, Suotang ^{[1
]}

机构：

[1] Shanxi Univ, Coll Phys & Elect Engn, State Key Lab Quantum Opt & Quantum Opt Devices, Taiyuan 030006, Peoples R China

来源：

PHYSICAL REVIEW A | 2007年 / 76卷 / 06期

关键词：

D O I：

10.1103/PhysRevA.76.063820

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Mandel's Q parameter, which is determined from single-event photon statistics, provides an alternative way to recognize single molecules with fluorescence detection, other than the second-order correlation function. It is shown that the Q parameter of an assumed ideal double-molecule fluorescence with the same average photon number as that of the sample fluorescence can act as the criterion for single-molecule recognition. The influence of signal-to-background ratio and the error estimates for photon statistics are also presented. We have applied this method to ascertain single Cy5 dye molecules within hundreds of milliseconds.

引用

页数：7

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