Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells

被引：11

作者：

Wang, Chih-Chiang ^{[1
]}

Yang, Chih-Jen ^{[2
,3
,4
]}

Wu, Li-Hsien ^{[5
]}

Lin, Han-Chen ^{[6
]}

Wen, Zhi-Hong ^{[7
]}

Lee, Che-Hsin ^{[8
,9
]}

机构：

[1] Kaohsiung Armed Forces Gen Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Internal Med, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Resp Therapy, Kaohsiung, Taiwan

[5] China Med Univ, Dept Publ Hlth, Taichung, Taiwan

[6] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Anat, Kaohsiung, Taiwan

[7] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung, Taiwan

[8] Natl Sun Yat Sen Univ, Dept Biol Sci, 70 Lienhai Rd, Kaohsiung 80424, Taiwan

[9] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2018年 / 15卷 / 12期

关键词：

Eicosapentaenoic acid; tumor microenvironment; indoleamine 2,3-dioxygenase; immune evasion; immunotherapy; DENDRITIC CELLS; DOWN-REGULATION; BREAST-CANCER; INHIBITION; MELANOGENESIS; ACTIVATION; AUTOPHAGY; TOLERANCE; EPA;

D O I：

10.7150/ijms.27326

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Marine plants and animals have omega-3 fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA is required for biological processes, but humans are unable to synthesize them and must be obtained from dietary sources. EPA has been used as an antitumor agent but the molecular mechanisms for the regulation of tumor microenvironment immunity by EPA are still unknown. The indoleamine 2,3-dioxygenase 1 (IDO) catalyzes conversion of tryptophan to kynurenine to induce immune evasion in tumor microenvironment. In this study, EPA inhibited the expression of IDO via downregulation of protein kinase B (Akt)/mammalian targets of rapamycin (mTOR) signaling pathway in tumor cells. Meanwhile, a significant decrease in kynurenine levels and increase in T cell survival were observed after tumor cells treated with EPA. The results demonstrated that EPA can activate host antitumor immunity by inhibiting tumor IDO expression. Therefore, our finding suggests that EPA can be enormous potential for cancer immunotherapy.

引用

页码：1296 / 1303

页数：8

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