First stereoselective total synthesis of paecilomycin G

被引：10

作者：

Bujaranipalli, Sheshurao ^{[1
]}

Das, Saibal ^{[1
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 25期

关键词：

Stereoselective synthesis; Resorcylic acid lactone; Jacobsen's hydrolytic kinetic resolution; Sharpless asymmetric dihydroxylation; Stille coupling; Metathesis reaction; RESORCYLIC ACID LACTONES; ASYMMETRIC TOTAL-SYNTHESIS; RADICICOL; METABOLITES; MACROLIDES; FACILE;

D O I：

10.1016/j.tetlet.2016.05.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective total synthesis of resorcylic acid lactone, paecilomycin G (1) has been accomplished. The key steps involved are the Corey Fuchs reaction, Sharpless asymmetric dihydroxylation, Jacobsen hydrolytic kinetic resolution, Stille coupling, Mitsunobu reaction, and Ring-closing metathesis (RCM) reaction. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2800 / 2802

页数：3

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