共 28 条
Experimental annotation of the human genome using microarray technology
被引:325
作者:

Shoemaker, DD
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Schadt, EE
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Armour, CD
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

He, YD
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Garrett-Engele, P
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

McDonagh, PD
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Loerch, PM
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Leonardson, A
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Lum, PY
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Cavet, G
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Wu, LF
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Altschuler, SJ
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Edwards, S
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

King, J
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Tsang, JS
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Schimmack, G
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Schelter, JM
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Koch, J
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Ziman, M
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Marton, MJ
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Li, B
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Cundiff, P
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Ward, T
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Castle, J
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Krolewski, M
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Meyer, MR
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Mao, M
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Burchard, J
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Kidd, MJ
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Dai, H
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Phillips, JW
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Linsley, PS
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Stoughton, R
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Scherer, S
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机构:
Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA

Boguski, MS
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Rosetta Inpharmat Inc, Kirkland, WA 98034 USA Rosetta Inpharmat Inc, Kirkland, WA 98034 USA
机构:
[1] Rosetta Inpharmat Inc, Kirkland, WA 98034 USA
来源:
关键词:
D O I:
10.1038/35057141
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The most important product of the sequencing of a genome is a complete, accurate catalogue of genes and their products, primarily messenger RNA transcripts and their cognate proteins. Such a catalogue cannot be constructed by computational annotation alone; it requires experimental validation on a genome scale. Using 'exon' and 'tiling' arrays fabricated by ink-jet oligonucleotide synthesis, we devised an experimental approach to validate and refine computational gene predictions and define full-length transcripts on the basis of co-regulated expression of their exons. These methods can provide more accurate gene numbers and allow the detection of mRNA splice variants and identification of the tissue- and disease-specific conditions under which genes are expressed. We apply our technique to chromosome 22q under 69 experimental condition pairs, and to the entire human genome under two experimental conditions. We discuss implications for more comprehensive, consistent and reliable genome annotation, more efficient, full-length complementary DNA cloning strategies and application to complex diseases.
引用
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页码:922 / +
页数:7
相关论文
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Zago, MA
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Andrade, LEC
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Carrer, H
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Goldman, GH
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Gruber, A
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Hackel, C
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Marie, SKN
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Rogatto, SR
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da Silva, IDCG
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Acencio, M
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Ho, PL
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