Comet Assay in Neonatal Sepsis

被引：7

作者：

Carvalho, Natalia C. ^{[1
]}

de Souza, Rozilda L. ^{[1
]}

Dal-Pizzol, Felipe ^{[2
]}

Andrade, Vanessa M. ^{[1
]}

机构：

[1] Univ Extremo Sul Catarinense UNESC, Programa Posgrad Ciencias Saude, Lab Imunol & Mutagenese, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil

[2] Univ Extremo Sul Catarinense UNESC, Programa Posgrad Ciencias Saude, Lab Fisiopatol Expt, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil

来源：

INDIAN JOURNAL OF PEDIATRICS | 2010年 / 77卷 / 08期

关键词：

Comet assay; Exposure biomarker; Neonatal sepsis;

D O I：

10.1007/s12098-010-0127-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective. To determine whether the DNA damage detected using the Comet assay helps in the diagnosis of neonatal sepsis Methods. Sepsis was diagnosed, based on clinical findings, laboratory findings and positive culture results, in 24 of the 48 newborns who participated in the study. Hematological parameters, baseline demographic data and genotoxic evaluation were investigated. Results. There were no significant differences in hematological, demographic and genotoxic data between cases and controls. Conclusions. The Comet assay proved to be ineffective in the diagnosis of neonatal sepsis. [Indian J Pediatr 2010; 77 (8): 875-877] E-mail: vmoraesdeandrade@ yahoo.com.br

引用

页码：875 / 877

页数：3

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