IL-1 receptor antagonist gene polymorphism in idiopathic recurrent spontaneous abortion in a Chinese Han population

被引：10

作者：

Dai, M. Z. ^{[1
]}

Pan, Y. Q. ^{[1
]}

Xu, D. P. ^{[1
]}

Chen, X. J. ^{[1
]}

Qian, R. J. ^{[2
]}

Chen, D. H. ^{[2
]}

Cui, T. W. ^{[2
]}

Lin, A. ^{[1
,3
]}

Yan, W. H. ^{[1
]}

机构：

[1] Taizhou Hosp, Wenzhou Med Coll, Med Res Ctr, Linhai 317000, Zhejiang, Peoples R China

[2] Taizhou Hosp, Human Tissue Bank, Wenzhou Med Coll, Linhai 317000, Zhejiang, Peoples R China

[3] Wenzhou Med Coll, Dept Biotechnol, Sch Life Sci, Wenzhou, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2010年 / 37卷 / 05期

关键词：

PREGNANCY LOSS; PROMOTER REGION; PRETERM BIRTH; INTERLEUKIN-1; WOMEN; CYTOKINE; MISCARRIAGE; INTRON-2; DISEASE; EPIDEMIOLOGY;

D O I：

10.1111/j.1744-313X.2010.00939.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

P>Interleukin-1 receptor antagonist (IL-1Ra) has been supposed to play important roles in pregnancy. The purpose of this study was to evaluate the association between the polymorphisms of IL-1Ra gene (IL1RN) variable number tandem repeat (VNTR) in intron 2 with idiopathic recurrent spontaneous abortion (RSA). Ninety-two RSA patients and hundred normal women with at least one live birth and no history of miscarriage were included in the study. Frequencies of the IL1RN alleles and genotypes were determined. Data revealed that the prevalence of IL1RN allele and genotype was not significant between the RSA and control group (all P > 0.05). Our finding indicated that the polymorphism VNTR of IL1RN gene in intron 2 may not be a risk factor for RSA in the Chinese Han population.

引用

页码：393 / 396

页数：4

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