Elevated levels of impulsivity and reduced place conditioning with d-amphetamine:: Two behavioral features of adolescence in mice

被引:128
作者
Adriani, W [1 ]
Laviola, G [1 ]
机构
[1] Ist Super Sanita, Lab Fisiopatol OS, Sect Behav Pathophysiol, I-00161 Rome, Italy
关键词
D O I
10.1037/0735-7044.117.4.695
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Human adolescents may have experience with easily available psychoactive drugs. Impulsivity and/or peculiarities in reward systems may play a role. These variables were studied in adolescent (Postnatal Day [PND] 30-49) and adult (PND > 60) CD-1 mice. In Experiment 1 (impulsivity), food-restricted mice were tested in operant chambers with 2 nose-poking holes that delivered 1 food pellet immediately or 5 pellets after a delay. respectively. Delay length was increased over days (0-100 s). Adolescent mice showed a shift to the left in the intolerance-delay curve, as welt as enhanced demanding when nose-poking was not reinforced. In Experiment 2 (place conditioning with d-amphetamine at 0.0. 1.0 2.0, 3.3, or 5.0 mg/kg for 3 days), adolescent mice showed no reliable evidence of place conditioning when compared with adults. Hence, 2 main features of adolescence were elevated impulsivity and restlessness, and low (or absent) rewarding efficacy of amphetamine.
引用
收藏
页码:695 / 703
页数:9
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