Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

被引：419

作者：

Vila, Arnau Vich ^{[1
,2
,3
]}

Imhann, Floris ^{[1
,2
,3
]}

Collij, Valerie ^{[1
,2
,3
]}

Jankipersadsing, Soesma A. ^{[1
,3
]}

Gurry, Thomas ^{[4
,5
]}

Mujagic, Zlatan ^{[6
]}

Kurilshikov, Alexander ^{[1
,3
]}

Bonder, Marc Jan ^{[1
,3
]}

Jiang, Xiaofang ^{[4
,5
]}

Tigchelaar, Ettje F. ^{[1
,3
]}

Dekens, Jackie ^{[1
,3
]}

Peters, Vera ^{[1
,2
]}

Voskuil, Michiel D. ^{[1
,2
,3
]}

Visschedijk, Marijn C. ^{[1
,2
,3
]}

van Dullemen, Hendrik M. ^{[1
,2
]}

Keszthelyi, Daniel ^{[6
]}

Swertz, Morris A. ^{[1
,3
]}

Franke, Lude ^{[1
,3
]}

Alberts, Rudi ^{[1
,2
,3
]}

Festen, Eleonora A. M. ^{[1
,2
,3
]}

Dijkstra, Gerard ^{[1
,2
]}

Masclee, Ad A. M. ^{[6
]}

Hofker, Marten H. ^{[1
,7
]}

Xavier, Ramnik J. ^{[4
,5
]}

Alm, Eric J. ^{[4
,5
]}

Fu, Jingyuan ^{[1
,3
,7
]}

Section, Cisca Wijmenga ^{[1
,3
]}

Section, Daisy M. A. E. Jonkers ^{[6
]}

Zhernakova, Alexandra ^{[1
,3
]}

Weersma, Rinse K. ^{[1
,2
]}

机构：

[1] Univ Groningen, Groningen, Netherlands

[2] Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands

[3] Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

[4] MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Broad Inst Harvard & MIT, Cambridge, MA USA

[6] Maastricht Univ, Med Ctr, Div Gastroenterol Hepatol, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands

[7] Univ Med Ctr Groningen, Dept Pediat, Groningen, Netherlands

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2018年 / 10卷 / 472期

关键词：

RESISTANCE; IDENTIFICATION; INTESTINE; ALIGNMENT; MARKERS; IRON;

D O I：

10.1126/scitranslmed.aap8914

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Changes in the gut microbiota have been associated with two of the most common gastrointestinal diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Here, we performed a case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population. Despite substantial overlap between the gut microbiome of patients with IBD and IBS compared with control individuals, we were able to use gut microbiota composition differences to distinguish patients with IBD from those with IBS. By combining species-level profiles and strain-level profiles with bacterial growth rates, metabolic functions, antibiotic resistance, and virulence factor analyses, we identified key bacterial species that may be involved in two common gastrointestinal diseases.

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页数：11

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