Clinical evaluation of bempedoic acid for the treatment of hyperlipidaemia

被引：7

作者：

Averna, Maurizio ^{[1
]}

Bilato, Claudio ^{[2
]}

Sesti, Giorgio ^{[3
]}

机构：

[1] Univ Palermo, Dept Hlth Promot Sci Maternal & Infantile Care, Internal Med & Med Special, Palermo, Italy

[2] Azienda ULSS 8, Dept Cardiovasc Med, Vicenza, Italy

[3] Univ Roma La Sapienza, Dept Clin & Mol Med, Rome, Italy

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2022年 / 32卷 / 01期

关键词：

Bempedoic acid; ATP citrate lyase; LDL-cholesterol; Lipid-lowering treatment; Novel LDL-C treatment;

D O I：

10.1016/j.numecd.2021.09.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bempedoic acid (BA) is a novel first-in-class oral lipid-lowering therapy. BA has been approved by the European Medicinal Agency and Food and Drug Administration and has been commercialised throughout Europe since the end of 2020 as an add-on therapy in patients at high/very-high cardiovascular risk that are not at LDL-C goals with current lipid-lowering treatments. Recently, Italian lipid management experts gathered to discuss several open questions on BA characteristics and BArelated practical clinical issues. The panel permitted collection of its opinions in a ten Q&A format. Aim: The aim of this viewpoint is to discuss and answer several open questions on BA characteristics and BA-related practical clinical issues. Data synthesis: The data includes main phase III studies, subanalysis and meta-analysis on BA. Conclusions: The panel permitted collection of its opinions in a ten Q&A format. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：17 / 20

页数：4

共 18 条

[1] Bempedoic acid plus ezetimibe fixed-dose combination in patients with hypercholesterolemia and high CVD risk treated with maximally tolerated statin therapy [J].

Ballantyne, Christie M. ;

Laufs, Ulrich ;

Ray, Kausik K. ;

Leiter, Lawrence A. ;

Bays, Harold E. ;

Goldberg, Anne C. ;

Stroes, Erik S. G. ;

MacDougall, Diane ;

Zhao, Xin ;

Catapano, Alberico L. .

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2020, 27 (06) :593-603

[2] Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study [J].

Ballantyne, Christie M. ;

Banach, Maciej ;

Mancini, G. B. John ;

Lepor, Norman E. ;

Hanselman, Jeffrey C. ;

Zhao, Xin ;

Leiter, Lawrence A. .

ATHEROSCLEROSIS, 2018, 277 :195-203

[3]

Ballantyne CM, 2020, EUROPEAN SOC CARDIOL

[4] Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia [J].

Banach, Maciej ;

Duell, P. Barton ;

Gotto, Antonio M., Jr. ;

Laufs, Ulrich ;

Leiter, Lawrence A. ;

Mancini, G. B. John ;

Ray, Kausik K. ;

Flaim, JoAnn ;

Ye, Zhan ;

Catapano, Alberico L. .

JAMA CARDIOLOGY, 2020, 5 (10) :1124-1135

[5] Bempedoic acid safety analysis: Pooled data from four phase 3 clinical trials [J].

Bays, Harold E. ;

Banach, Maciej ;

Catapano, Alberico L. ;

Duell, P. Barton ;

Gotto, Antonio M., Jr. ;

Laufs, Ulrich ;

Leiter, Lawrence A. ;

Mancini, G. B. John ;

Ray, Kausik K. ;

Bloedon, LeAnne T. ;

Sasiela, William J. ;

Ye, Zhan ;

Ballantyne, Christie M. .

JOURNAL OF CLINICAL LIPIDOLOGY, 2020, 14 (05) :649-+

[6] 2020 American College of Rheumatology Guideline for the Management of Gout [J].

FitzGerald, John D. ;

Dalbeth, Nicola ;

Mikuls, Ted ;

Brignardello-Petersen, Romina ;

Guyatt, Gordon ;

Abeles, A. M. ;

Gelber, Allan C. ;

Harrold, Leslie R. ;

Khanna, Dinesh ;

King, Charles ;

Levy, Gerald ;

Libbey, Caryn ;

Mount, David ;

Pillinger, Michael H. ;

Rosenthal, Ann ;

Singh, Jasvinder A. ;

Sims, James Edward ;

Smith, Benjamin J. ;

Wenger, Neil S. ;

Sharon, Sangmee ;

Danve, Abhijeet ;

Khanna, Puja P. ;

Kim, Seoyoung C. ;

Lenert, Aleksander ;

Poon, Samuel ;

Qasim, Anila ;

Sehra, Shiv T. ;

Sharma, Tarun Sudhir Kumar ;

Toprover, Michael ;

Turgunbaev, Marat ;

Zeng, Linan ;

Zhang, Mary Ann ;

Turner, Amy S. ;

Neogi, Tuhina .

ARTHRITIS CARE & RESEARCH, 2020, 72 (06) :744-760

[7] Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial [J].

Goldberg, Anne C. ;

Leiter, Lawrence A. ;

Stroes, Erik S. G. ;

Baum, Seth J. ;

Hanselman, Jeffrey C. ;

Bloedon, LeAnne T. ;

Lalwani, Narendra D. ;

Patel, Pragna M. ;

Zhao, Xin ;

Duell, P. Barton .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (18) :1780-1788

[8] Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults The ALLHAT-LLT Randomized Clinical Trial [J].

Han, Benjamin H. ;

Sutin, David ;

Williamson, Jeff D. ;

Davis, Barry R. ;

Piller, Linda B. ;

Pervin, Hannah ;

Pressel, Sara L. ;

Blaum, Caroline S. .

JAMA INTERNAL MEDICINE, 2017, 177 (07) :955-965

[9] Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance [J].

Laufs, Ulrich ;

Banach, Maciej ;

Mancini, G. B. John ;

Gaudet, Daniel ;

Bloedon, LeAnne T. ;

Sterling, Lulu Ren ;

Kelly, Stephanie ;

Stroes, Erik S. G. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2019, 8 (07)

[10] 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) [J].

Mach, Francois ;

Baigent, Colin ;

Catapano, Alberico L. ;

Koskinas, Konstantinos C. ;

Casula, Manuela ;

Badimon, Lina ;

Chapman, M. John ;

De Backer, Guy G. ;

Delgado, Victoria ;

Ference, Brian A. ;

Graham, Ian M. ;

Halliday, Alison ;

Landmesser, Ulf ;

Mihaylova, Borislava ;

Pedersen, Terje R. ;

Riccardi, Gabriele ;

Richter, Dimitrios J. ;

Sabatine, Marc S. ;

Taskinen, Marja-Riitta ;

Tokgozoglu, Lale ;

Wiklund, Olov ;

Mueller, Christian ;

Drexel, Heinz ;

Aboyans, Victor ;

Corsini, Alberto ;

Doehner, Wolfram ;

Farnier, Michel ;

Gigante, Bruna ;

Kayikcioglu, Meral ;

Krstacic, Goran ;

Lambrinou, Ekaterini ;

Lewis, Basil S. ;

Masip, Josep ;

Moulin, Philippe ;

Petersen, Steffen ;

Petronio, Anna Sonia ;

Piepoli, Massimo Francesco ;

Pinto, Xavier ;

Raber, Lorenz ;

Ray, Kausik K. ;

Reiner, Zeljko ;

Riesen, Walter F. ;

Roffi, Marco ;

Schmid, Jean-Paul ;

Shlyakhto, Evgeny ;

Simpson, Iain A. ;

Stroes, Erik ;

Sudano, Isabella ;

Tselepis, Alexandros D. ;

Viigimaa, Margus .

EUROPEAN HEART JOURNAL, 2020, 41 (01) :111-188

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