The catalytic mechanism of cytochrome P450 BM3 involves a 6 angstrom movement of the bound substrate on reduction

被引：126
作者：
Modi, S
Sutcliffe, MJ
Primrose, WU
Lian, LY
Roberts, GCK
机构：
[1] UNIV LEICESTER, DEPT BIOCHEM, LEICESTER LE1 9HN, LEICS, ENGLAND
[2] UNIV LEICESTER, DEPT CHEM, LEICESTER LE1 9HN, LEICS, ENGLAND
[3] UNIV LEICESTER, BIOL NMR CTR, LEICESTER LE1 9HN, LEICS, ENGLAND
[4] UNIV LEICESTER, CTR MECH HUMAN TOX, LEICESTER LE1 9HN, LEICS, ENGLAND
来源：
NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 05期
关键词：
D O I：
10.1038/nsb0596-414
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Paramagnetic relaxation measurements show that reduction of the cytochrome P450 BM3-substrate complex is accompanied by a structural change leading to a 6 Angstrom, movement of the substrate into the correct position and orientation for hydroxylation.
引用
收藏
页码：414 / 417
页数：4
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