Genetic predisposition to severe myoclonic epilepsy in infancy

被引：29

作者：

Benlounis, A

Nabbout, R

Feingold, J

Parmeggiani, A

Guerrini, R

Kaminska, A

Dulac, O

机构：

[1] Hop St Vincent de Paul, Dept Neuropediat, F-75674 Paris, France

[2] Hop La Pitie Salpetriere, INSERM, U289, Paris, France

[3] Univ Bologna, Dept Child Neurol & Psychiat, Bologna, Italy

[4] Univ Pisa, Inst Child Neurol & Psychiat, Pisa, Italy

来源：

EPILEPSIA | 2001年 / 42卷 / 02期

基金：

美国国家科学基金会;

关键词：

genetics of epilepsy; severe myoclonic epilepsy in infancy; epilepsy in infancy; febrile convulsions; absence epilepsy; idiopathic generalized epilepsy;

D O I：

10.1046/j.1528-1157.2001.25299.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: To address genetic predisposition to febrile convulsions (FCs) and epilepsy as an etiologic background of severe myoclonic epilepsy in infancy (SMEI). Methods: Familial antecedents of epilepsy and FCs were analyzed in four groups of patients with SMEI (65 cases), FCs (57 cases), childhood absences (67 cases), and a control group of patients with no neurologic problems (64 cases). Results: Patients with SMEI and those with FCs had significantly increased incidence of FCs in their relatives compared with those with absence epilepsy and with the control group. The incidence of epilepsy in relatives of patients with SMEI and absence epilepsy was increased compared with that in the control group and reached statistical significance. Epilepsy in relatives with SMEI had the characteristics of idiopathic generalized epilepsy. Conclusions: A genetic predisposition could determine three types of epileptic syndromes: FCs, idiopathic generalized epilepsy, and SMEI.

引用

页码：204 / 209

页数：6

共 19 条

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