The evolution of genetic structure in the marine pathogen, Vibrio vulnificus

被引:48
作者
Bisharat, Naiel
Cohen, Daniel I.
Maiden, Martin C.
Crook, Derrick W.
Peto, Tim
Harding, Rosalind M.
机构
[1] Tel Aviv Univ, Sackler Fac Med, Dept Epidemiol & Prevent Med, Ramat Aviv, Israel
[2] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
[3] Univ Oxford, Dept Stat, Oxford OX1 3TG, England
[4] Univ Oxford, John Radcliffe Hosp, Nuffield Dept, Clin Sci Lab, Oxford OX3 9DU, England
[5] Univ Oxford, John Radcliffe Hosp, Acad Dept Microbiol & Infect Dis, Oxford OX3 9DU, England
基金
英国惠康基金;
关键词
recombination; linkage disequilibrium; Vibrio vulnificus; sequence diversity; clonal frame; coalescence-based methods;
D O I
10.1016/j.meegid.2007.07.007
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Multi-locus sequence types (MLST) from a global collection of Vibrio vulnificus isolates were analysed for the contribution of recombination to the evolution of two divergent clusters of strains and a human-pathogenic hybrid genotype, which caused a disease outbreak in Israel. Recombination contributes more substantially than mutation to generating strain diversity. For allelic diversity within loci, the ratio of recombination to mutation events is approximately 2:1. The role of recombination relative to mutation in the generation of new MLST variants of V. vulnificus within the clusters is comparable to that of other highly recombining bacteria such as Neisseria meningitidis. However, across the divide between the two major clusters of V. vulnificus strains, there is substantial linkage disequilibrium, lower estimates for recombination rates and shorter estimates of recombination tract length. We account for these differences between V. vulnificus and N. meningitidis by attributing them to the presence of the unusual genetic structure within V. vulnificus. The reason for the presence of distinct and divergent genomes remains unresolved. Two possible explanations put forward for future study are first, ecologically based population structure within V. vulnificus and second, a recombination donor from a phenotypically differentiated species. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:685 / 693
页数:9
相关论文
共 34 条
  • [1] Arias CR, 1998, APPL ENVIRON MICROB, V64, P3403
  • [2] Vibrio coralliilyticus sp nov., a temperature-dependent pathogen of the coral Pocillopora damicornis
    Ben-Haim, Y
    Thompson, FL
    Thompson, CC
    Cnockaert, MC
    Hoste, B
    Swings, J
    Rosenberg, E
    [J]. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2003, 53 : 309 - 315
  • [3] Hybrid Vibrio vulnificus
    Bisharat, N
    Cohen, DI
    Harding, RM
    Falush, D
    Crook, DW
    Peto, T
    Maiden, MC
    [J]. EMERGING INFECTIOUS DISEASES, 2005, 11 (01) : 30 - 35
  • [4] Clinical, epidemiological, and microbiological features of Vibrio vulnificus biogroup 3 causing outbreaks of wound infection and bacteraemia in Israel
    Bisharat, N
    Agmon, V
    Finkelstein, R
    Raz, R
    Ben-Dror, G
    Lerner, L
    Soboh, S
    Colodner, R
    Cameron, DN
    Wykstra, DL
    Swerdlow, DL
    Farmer, JJ
    [J]. LANCET, 1999, 354 (9188) : 1421 - 1424
  • [5] DISEASE CAUSED BY A MARINE VIBRIO - CLINICAL CHARACTERISTICS AND EPIDEMIOLOGY
    BLAKE, PA
    MERSON, MH
    WEAVER, RE
    HOLLIS, DG
    HEUBLEIN, PC
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1979, 300 (01) : 1 - 5
  • [6] Recombination estimation under complex evolutionary models with the coalescent composite-likelihood method
    Carvajal-Rodríguez, A
    Crandall, KA
    Posada, D
    [J]. MOLECULAR BIOLOGY AND EVOLUTION, 2006, 23 (04) : 817 - 827
  • [7] Comparative genome analysis of Vibrio vulnificus, a marine pathogen
    Chen, CY
    Wu, KM
    Chang, YC
    Chang, CH
    Tsai, HC
    Liao, TL
    Liu, YM
    Chen, HJ
    Shen, ABT
    Li, JC
    Su, TL
    Shao, CP
    Lee, CT
    Hor, LI
    Tsai, SF
    [J]. GENOME RESEARCH, 2003, 13 (12) : 2577 - 2587
  • [8] Analysis of Vibrio vulnificus from market oysters and septicemia cases for virulence markers
    DePaola, A
    Nordstrom, JL
    Dalsgaard, A
    Forslund, A
    Oliver, J
    Bates, T
    Bourdage, KL
    Gulig, PA
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2003, 69 (07) : 4006 - 4011
  • [9] Inference of bacterial microevolution using multilocus sequence data
    Didelot, Xavier
    Falush, Daniel
    [J]. GENETICS, 2007, 175 (03) : 1251 - 1266
  • [10] Inference of viral evolutionary rates from molecular sequences
    Drummond, A
    Pybus, OG
    Rambaut, A
    [J]. ADVANCES IN PARASITOLOGY, VOL 54: THE EVOLUTION OF PARASITISM-A PHYLOGENETIC PERSPECTIVE, 2003, 54 : 331 - 358