Enantioselective Total Synthesis of the Selective PI3 Kinase Inhibitor Liphagal

被引：40

作者：

Alvarez-Manzaneda, Enrique ^{[1
]}

Chahboun, Rachid ^{[1
]}

Alvarez, Esteban ^{[1
]}

Cano, M. Jose ^{[1
]}

Haidour, Ali ^{[1
]}

Alvarez-Manzaneda, Ramon ^{[2
]}

机构：

[1] Univ Granada, Fac Ciencias, Dept Quim Organ, Inst Biotecnol, E-18071 Granada, Spain

[2] Univ Almeria, Fac Ciencias, Dept Quim Organ, Almeria 04120, Spain

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 20期

关键词：

ABSOLUTE-CONFIGURATION; CYCLIZATION;

D O I：

10.1021/ol101173w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective total synthesis of liphagal, a selective inhibitor of PI3K alpha isolated from the marine sponge Aka coralliphaga, has been achieved. The novel tetracyclic "liphagane" skeleton is formed in one step, after the hydrogenation of a dihydroxydrimane phenol benzyl ether in the presence of cationic resin.

引用

页码：4450 / 4453

页数：4

共 24 条

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