Time and length scales of autocrine signals in three dimensions

被引：22

作者：

Coppey, Mathieu

Berezhkovskii, Alexander M.

Sealfon, Stuart C.

Shvartsman, Stanislav Y. ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem Engn, Princeton, NJ 08544 USA

[2] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[3] Math & Stat Comp Lab, Div Computat Biosci, Ctr Informat Technol, Natl Inst Hlth, Bethesda, MD USA

[4] CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA

[5] CUNY Mt Sinai Sch Med, Ctr Translat Syst Biol, New York, NY 10029 USA

来源：

BIOPHYSICAL JOURNAL | 2007年 / 93卷 / 06期

关键词：

D O I：

10.1529/biophysj.107.109736

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.

引用

页码：1917 / 1922

页数：6

共 32 条

[1]

Abramowitz M., 1964, Handbook of mathematical tables with formulas, graphs, and mathematical tables

[2] Stochastic model of autocrine and paracrine signals in cell culture assays [J].