Effect of Acyclovir on HIV-1 Set Point among Herpes Simplex Virus Type 2-Seropositive Persons during Early HIV-1 Infection

被引：9

作者：

Kim, H. Nina ^{[1
,4
]}

Wang, Jing ^{[7
]}

Hughes, James ^{[7
]}

Coombs, Robert ^{[2
,4
,5
]}

Sanchez, Jorge ^{[11
]}

Reid, Stewart ^{[8
,12
]}

Delany-Moretlwe, Sinead ^{[13
]}

Cowan, Frances ^{[14
]}

Fuchs, Jonathan ^{[9
,11
]}

Eshleman, Susan H. ^{[10
]}

Khaki, Leila ^{[7
]}

McMahon, Moira A. ^{[10
]}

Siliciano, Robert F. ^{[10
]}

Wald, Anna ^{[4
,7
]}

Celum, Connie ^{[3
,4
,6
]}

机构：

[1] Univ Washington, Harborview Med Ctr, Sch Med, Dept Med, Seattle, WA 98104 USA

[2] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98104 USA

[3] Univ Washington, Sch Med, Dept Global Hlth, Seattle, WA 98104 USA

[4] Univ Washington, Sch Publ Hlth, Dept Med, Seattle, WA 98104 USA

[5] Univ Washington, Sch Publ Hlth, Dept Lab Med, Seattle, WA 98104 USA

[6] Univ Washington, Sch Publ Hlth, Dept Global Hlth, Seattle, WA 98104 USA

[7] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA

[8] Univ Alabama, Dept Med, Birmingham, AL 35294 USA

[9] San Francisco Dept Publ Hlth, San Francisco, CA USA

[10] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[11] Asociac Civil Impacta Salud & Educ IMPACTA, Lima, Peru

[12] Ctr Infect Dis Res Zambia, Lusaka, Zambia

[13] Univ Witwatersrand, Reprod Hlth Unit, Johannesburg, South Africa

[14] UCL, London, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 05期

基金：

美国国家卫生研究院;

关键词：

REVERSE-TRANSCRIPTASE; SEROCONVERSION; ACQUISITION; RESISTANCE; MUTATION; COHORT; UGANDA; TRIAL; RAKAI; MEN;

D O I：

10.1086/655662

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated whether acyclovir suppression during human immunodeficiency virus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects reverse-transcriptase mutations among 76 HIV-1 seroconverters identified in a placebo-controlled trial of twice-daily acyclovir (400 mg) for the prevention of HIV acquisition in herpes simplex virus type 2 (HSV-2)-seropositive persons (HIV Prevention Trials Network study 039). We found no significant difference in plasma HIV-1 RNA levels (Pp. 30) or CD4 cell counts (Pp. 85) between the acyclovir and placebo recipients. V75I and other mutations in HIV-1 reverse transcriptase reported from in vitro acyclovir studies were not observed. In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point.

引用

页码：734 / 738

页数：5

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