Effect of Acyclovir on HIV-1 Set Point among Herpes Simplex Virus Type 2-Seropositive Persons during Early HIV-1 Infection

被引：9

作者：

Kim, H. Nina ^{[1
,4
]}

Wang, Jing ^{[7
]}

Hughes, James ^{[7
]}

Coombs, Robert ^{[2
,4
,5
]}

Sanchez, Jorge ^{[11
]}

Reid, Stewart ^{[8
,12
]}

Delany-Moretlwe, Sinead ^{[13
]}

Cowan, Frances ^{[14
]}

Fuchs, Jonathan ^{[9
,11
]}

Eshleman, Susan H. ^{[10
]}

Khaki, Leila ^{[7
]}

McMahon, Moira A. ^{[10
]}

Siliciano, Robert F. ^{[10
]}

Wald, Anna ^{[4
,7
]}

Celum, Connie ^{[3
,4
,6
]}

机构：

[1] Univ Washington, Harborview Med Ctr, Sch Med, Dept Med, Seattle, WA 98104 USA

[2] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98104 USA

[3] Univ Washington, Sch Med, Dept Global Hlth, Seattle, WA 98104 USA

[4] Univ Washington, Sch Publ Hlth, Dept Med, Seattle, WA 98104 USA

[5] Univ Washington, Sch Publ Hlth, Dept Lab Med, Seattle, WA 98104 USA

[6] Univ Washington, Sch Publ Hlth, Dept Global Hlth, Seattle, WA 98104 USA

[7] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA

[8] Univ Alabama, Dept Med, Birmingham, AL 35294 USA

[9] San Francisco Dept Publ Hlth, San Francisco, CA USA

[10] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[11] Asociac Civil Impacta Salud & Educ IMPACTA, Lima, Peru

[12] Ctr Infect Dis Res Zambia, Lusaka, Zambia

[13] Univ Witwatersrand, Reprod Hlth Unit, Johannesburg, South Africa

[14] UCL, London, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 05期

基金：

美国国家卫生研究院;

关键词：

REVERSE-TRANSCRIPTASE; SEROCONVERSION; ACQUISITION; RESISTANCE; MUTATION; COHORT; UGANDA; TRIAL; RAKAI; MEN;

D O I：

10.1086/655662

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated whether acyclovir suppression during human immunodeficiency virus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects reverse-transcriptase mutations among 76 HIV-1 seroconverters identified in a placebo-controlled trial of twice-daily acyclovir (400 mg) for the prevention of HIV acquisition in herpes simplex virus type 2 (HSV-2)-seropositive persons (HIV Prevention Trials Network study 039). We found no significant difference in plasma HIV-1 RNA levels (Pp. 30) or CD4 cell counts (Pp. 85) between the acyclovir and placebo recipients. V75I and other mutations in HIV-1 reverse transcriptase reported from in vitro acyclovir studies were not observed. In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point.

引用

页码：734 / 738

页数：5

共 50 条

[21] Precise Determination of Time to Reach Viral Load Set Point After Acute HIV-1 Infection
Huang, Xiaojie
Chen, Hui
Li, Wei
Li, Haiying
Jin, Xia
Perelson, Alan S.
Fox, Zoe
Zhang, Tong
Xu, Xiaoning
Wu, Hao
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2012, 61 (04) : 448 - 454
[22] Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines Among Sexual and Gender Minorities Living With and Without HIV-1 from Lagos, Nigeria
Aravantinou, Meropi
Plagianos, Marlena
Kokogho, Afoke
Adebajo, Sylvia G.
Nowak, Rebecca
Shoyemi, Elizabeth
Ekeh, Charles
Lombardi, Kara A.
Peel, Sheila D.
Baral, Stefan A.
Crowell, Trevor
Derby, Nina
Teleshova, Natalia
Martinelli, Elena
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2023, 39 (09) : 485 - 494
[23] Herpes Simplex Virus Type-2 Shedding and Genital Ulcers During Early HIV in Zimbabwean Women
Nowak, Rebecca G.
Liska, Tobias A.
Bentzen, Soren M.
Kim, Esther
Chipato, Tsungai
Salata, Robert A.
Celentano, David D.
Morrison, Charles S.
Gravitt, Patti E.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2021, 87 (02) : 789 - 793
[24] RAPID GENERATION OF SEQUENCE VARIATION DURING PRIMARY HIV-1 INFECTION
PANG, S
SHLESINGER, Y
DAAR, ES
MOUDGIL, T
HO, DD
CHEN, ISY
AIDS, 1992, 6 (05) : 453 - 460
[25] HIV-1 Transmission linkages among persons with incident infection to inform public health surveillance
Dennis, Ann M.
Frost, Simon D. W.
Enders, Kimberly
Cressman, Andrew E.
Volz, Erik
Adams, Nicole
Miller, William C.
Cohen, Myron S.
Mobley, Victoria
Samoff, Erika
Eron, Joseph J.
ECLINICALMEDICINE, 2021, 37
[26] Seroprevalence of herpes simplex virus type 1 among people living with HIV in Mbeya, Tanzania
Issakwisa, Habakkuk Mwakyula
Mbwile, Gloria Reginald
Mbwanji, Godlove Fred
Nassoro, David Daniel
Ntinginya, Nyanda Elias
Nsojo, Anthony Ambikile
BMC INFECTIOUS DISEASES, 2020, 20 (01)
[27] Genital Herpes Simplex Virus Type 2 Shedding Among Adults With and Without HIV Infection in Uganda
Phipps, Warren
Nakku-Joloba, Edith
Krantz, Elizabeth M.
Selke, Stacy
Huang, Meei-Li
Kambugu, Fred
Orem, Jackson
Casper, Corey
Corey, Lawrence
Wald, Anna
JOURNAL OF INFECTIOUS DISEASES, 2016, 213 (03): : 439 - 447
[28] Evaluation of a Highly Sensitive Qualitative Human Immunodeficiency Virus Type 1 (HIV-1) RNA Assay for Detection of HIV-1 Suppression
Nugent, C. Thomas
Nodelman, Vladislav
Giachetti, Cristina
Richman, Douglas D.
Looney, David J.
JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (03) : 833 - 836
[29] Herpes simplex virus type 2 associated with HIV infection among New York heterosexuals living in high-risk areas
Hagan, H.
Jenness, S. M.
Wendel, T.
Murrill, C. R.
Neaigus, A.
Gelpi-Acosta, C.
INTERNATIONAL JOURNAL OF STD & AIDS, 2010, 21 (08) : 580 - 583
[30] Development of a Multiplex Assay for Concurrent Diagnoses and Detection of HIV-1, HIV-2, and Recent HIV-1 Infection in a Single Test
Yufenyuy, Ernest L.
Parekh, Bharat S.
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2018, 34 (12) : 1017 - 1027

← 1 2 3 4 5 →