Current concepts from diagnosis to management in Gorham-Stout disease: a systematic narrative review of about 350 cases

被引：31
作者：
Angelini, Andrea [1 ]
Mosele, Nicolo [1 ]
Pagliarini, Elisa [1 ]
Ruggieri, Pietro [1 ]
机构：
[1] Univ Padua, Dept Orthoped & Orthoped Oncol, Padua, Italy
来源：
EFORT OPEN REVIEWS | 2022年 / 7卷 / 01期
关键词：
phantom bone disease; osteolysis; differential diagnosis; radiotherapy; bone tumors; treatment; diagnosis; symptoms; surgery; DISAPPEARING BONE-DISEASE; ENDOTHELIAL GROWTH-FACTOR; CHIARI I MALFORMATION; MASSIVE OSTEOLYSIS; SKULL BASE; ZOLEDRONIC ACID; CERVICAL-SPINE; FOLLOW-UP; OSTEOCLAST DIFFERENTIATION; TREATMENT OPTION;
D O I：
10.1530/EOR-21-0083
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Patients with Gorham-Stout disease (GSD) present progressive destruction and resorption of bone. Typical bone-related symptoms include swelling, pain and functional impairment in the region involved. The three aspects of GSD etiopathology are osteoclasts, angiogenesis/lymphangiogenesis and osteoblast function. Multi-targeted pharmacological approach includes innovative options and represent milestones of treatment, sometimes associated with radiotherapy. Surgery is mainly used to treat complications: pathologic/impending fractures, spinal instability or deformities and chylothorax. In this narrative review, we highlight current standards in diagnosis, clinical management and therapeutic strategies.
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收藏
页码：35 / 48
页数：14
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