Targeting T cells for asthma

被引：21
作者：
Heijink, IH
Van Oosterhout, AJM
机构：
[1] Univ Groningen, Med Ctr, Lab Allergol & Pulm Dis, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Med Ctr, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands
来源：
CURRENT OPINION IN PHARMACOLOGY | 2005年 / 5卷 / 03期
关键词：
D O I：
10.1016/j.coph.2005.04.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The type 2 T-helper (Th2) lymphocyte can be regarded as an important target cell for the treatment of allergic asthma as it plays a crucial role in the initiation, progression and persistence of disease. Several strategies to target Th2 cells can be envisioned. Drugs that prevent Th2-cells from migrating into the lung tissue, such as antibodies to the chemokine receptor CCR4 and inhibitors of the adhesion molecule VLA-4, are promising for the treatment of asthma. To inhibit Th2-cell activation, novel asthma drugs that act on Th2-selective transciption factors such as GATA3 are being developed. Although initial strategies aimed to block the action of Th2-derived cytokines, the generation of counter-regulatory Th1 lymphocytes and regulatory T cells is currently being explored.
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收藏
页码：227 / 231
页数：5
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