DNA Tunneling Detector Embedded in a Nanopore

被引:205
作者
Ivanov, Aleksandar P. [1 ]
Instuli, Emanuele [1 ]
McGilvery, Catriona M. [2 ]
Baldwin, Geoff [3 ]
McComb, David W. [2 ]
Albrecht, Tim [1 ]
Edel, Joshua B. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England
[2] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2AZ, England
[3] Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England
基金
英国工程与自然科学研究理事会; 英国惠康基金;
关键词
Nanopore sequencing; tunneling gap; DNA sequencing; label-free detection; ELECTRON-BEAM; BARRIER HEIGHT; TRANSPORT; SPECTROSCOPY; NUCLEOTIDES; JUNCTION;
D O I
10.1021/nl103873a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report on the fabrication and characterization of a DNA nanopore detector with integrated tunneling electrodes. Functional tunneling devices were identified by tunneling spectroscopy in different solvents and then used in proof-of-principle experiments demonstrating, for the first time, concurrent tunneling detection and ionic current detection of DNA molecules in a nanopore platform. This is an important step toward ultrafast DNA sequencing by tunneling.
引用
收藏
页码:279 / 285
页数:7
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