Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection

被引：59

作者：

Hajeer, Ali H. ^{[1
,3
]}

Balkhy, Hanan ^{[2
,4
]}

Johani, Sameera ^{[3
]}

Yousef, Mohammed Z. ^{[1
]}

Arabi, Yaseen ^{[4
,5
]}

机构：

[1] King Saud bin Abdulaziz Univ Hlth Sci, Dept Basic Med Sci, Riyadh, Saudi Arabia

[2] King Saud bin Abdulaziz Univ Hlth Sci, Dept Infect Prevent & Control, Riyadh, Saudi Arabia

[3] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, Dept Pathol & Lab, Riyadh, Saudi Arabia

[4] King Abdul Aziz Med City, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia

[5] King Abdul Aziz Med City, Dept Intens Care, Riyadh, Saudi Arabia

来源：

ANNALS OF THORACIC MEDICINE | 2016年 / 11卷 / 03期

关键词：

Human leukocyte Antigen Class II; Middle East respiratory syndrome-coronavirus; Saudi Arabia; HAPLOTYPE FREQUENCIES; HLA-A; -C; -DRB1; AND-DQB1;

D O I：

10.4103/1817-1737.185756

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia. AIM: We investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit. METHODS: A total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls. RESULTS: Two HLA class II alleles were associated with the disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome. CONCLUSIONS: Our results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be associated with susceptibility to MERS.

引用

页码：211 / 213

页数：3

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