Electrical stimulation in animal models of epilepsy: A review on cellular and electrophysiological aspects

被引:5
作者
Fiorin, Fernando da Silva [1 ]
Silva, Mariane de Araujo e [1 ]
Rodrigues, Abner Cardoso [1 ]
机构
[1] Edmond & Lily Safra Int, Santos Dumont Inst, Grad Program Neuroengn, Inst Neurosci, Edmond, OK, Brazil
关键词
Epilepsy; Inflammation; Electrical stimulation; Invasive methods; Semi-invasive methods; Non-invasive methods; VAGUS NERVE-STIMULATION; SPINAL-CORD STIMULATION; DEEP BRAIN-STIMULATION; INDUCED STATUS-EPILEPTICUS; CHRONIC NEUROPATHIC PAIN; TEMPORAL-LOBE EPILEPSY; QUALITY-OF-LIFE; LONG-TERM; RAT MODEL; FREQUENCY STIMULATION;
D O I
10.1016/j.lfs.2021.119972
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Epilepsy is a debilitating condition, primarily refractory individuals, leading to the search for new efficient therapies. Electrical stimulation is an important method used for years to treat several neurological disorders. Currently, electrical stimulation is used to reduce epileptic crisis in patients and shows promising results. Even though the use of electricity to treat neurological disorders has grown worldwide, there are still many caveats that must be clarified, such as action mechanisms and more efficient stimulation treatment parameters. Thus, this review aimed to explore the comprehension of the main stimulation methods in animal models of epilepsy using rodents to develop new experimental protocols and therapeutic approaches.
引用
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页数:12
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