Human genome and diseases:: Review immunology and functional genomics of Behcet's disease

被引:92
作者
Zierhut, M
Mizuki, N
Ohno, S
Inoko, H
Gül, A
Onoé, K
Isogai, E
机构
[1] Univ Tubingen, Dept Ophthalmol, D-72076 Tubingen, Germany
[2] Yokohama City Univ, Sch Med, Dept Ophthalmol, Yokohama, Kanagawa 232, Japan
[3] Tokai Univ, Sch Med, Div Mol Life Sci, Dept Genet Informat, Isehara, Kanagawa, Japan
[4] Hokkaido Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Sapporo, Hokkaido, Japan
[5] Istanbul Univ, Istanbul Fac Med, Dept Internal Med, Div Rheumatol, Istanbul, Turkey
[6] Hokkaido Univ, Inst Med Genet, Div Immunobiol, Sapporo, Hokkaido, Japan
[7] Hlth Sci Univ Hokkaido, Dept Prevent Dent, Sapporo, Hokkaido, Japan
关键词
Behcet's disease; vasculitis; uveitis; experimental autoimmume uveitis; HLA; streptococcus; herpes simplex virus; heat shock protein; T cells; NK-T-cells; neutrophils; cytokines; endothelial dysfunction; coagulation and fibrinolytic pathway abnormalities;
D O I
10.1007/s00018-003-2333-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Behcet's disease (BD) is a multisystemic inflammatory disorder. Although the cause and pathogenesis of BD are still unclear, there is evidence for genetic, immunologic and infectious factors at the onset or in the course of BD. This review focusses on the functional genomics and immunology of BD. HLA-B51 is the major disease susceptibility gene locus in BD. An increased number of gammadeltaT cells in the peripheral blood and in the involved tissues have been reported. However, the T cells at the sites of inflammation appear to be a phenotypically distinct subset. There is also a significant gammadelta T cell proliferative response to mycobacterial 65-kDa heat shock protein peptides. Homologous peptides derived from the human 60-kDa heat shock protein were observed in BD patients. There is evidence that natural killer T cells may also play a role in BD.
引用
收藏
页码:1903 / 1922
页数:20
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