Anti-inflammatory abietane diterpenoids from the seeds of Podocarpus nagi

被引：10

作者：

Feng, Zhe-Ling ^{[1
]}

Li, Dan ^{[1
]}

Liu, Qian-Yu ^{[1
]}

Liu, Jing-Xin ^{[1
]}

Huang, Li ^{[1
]}

Zhang, Qing-Wen ^{[1
]}

Wang, Yi-Tao ^{[1
]}

Lin, Li-Gen ^{[1
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2017年 / 21卷

关键词：

Podocarpus nagi; Abietane diterpenoids; NO production; Anti-inflammation; NORDITERPENE DILACTONES;

D O I：

10.1016/j.phytol.2017.07.011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In searching for naturally occurring anti-inflammatory agents, three new abietane-type diterpenoids, named 16-hydroxylambertic acid (1), 7-oxo-18-hydroxyferruginol (2), and 5 alpha, 12-dihydroxy-6-oxa-abieta-8,11,13-trien-7one (3), were isolated from the seeds of Podocarpus nagi, together with three known compounds. The structures of the new compounds were elucidated by extensive analysis of NMR and HR-ESIMS data. All the new compounds were tested for nitric oxide (NO) inhibitory activities on lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Compound 1 significantly inhibited NO production with IC50 value of 5.38 +/- 0.17 mu M, and suppressed inducible NO synthase (iNOS) expression in a dose-dependent manner, which were mediated through inhibiting the mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappa B) activation.

引用

页码：260 / 263

页数：4

共 14 条

[1] Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa [J].