A chimeric peptide that binds to titanium and mediates MC3T3-E1 cell adhesion

被引：9

作者：

Wang, Dan ^{[1
]}

Mao, Jing ^{[1
,2
]}

Zhou, Bin ^{[1
]}

Liao, Xiao-Fu ^{[1
]}

Gong, Shi-Qiang ^{[1
]}

Liu, Yan ^{[1
]}

Zhang, Jing-Tao ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Dept Nursing Sci, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2011年 / 33卷 / 01期

基金：

美国国家科学基金会;

关键词：

Cell adhesion; Chimeric peptide; MC3T3-E1; cell; Titanium; FORMATION IN-VIVO; RGD; HYDROXYAPATITE; SURFACE; IMPLANTS; BIOMATERIALS; MOTIF;

D O I：

10.1007/s10529-010-0411-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Purpose of work Our study provides a promising alternative of biomimetic coating which functionalizes the dental implant with adhesion peptides and may be useful for enhancing the bone remodeling around Ti implants. A chimeric peptide consisting of an Arg-Gly-Asp (RGD) sequence (mediating cell adhesion) and a RKLPDA (minTBP-1) sequence (specifically recognizing and binding to Ti substrate) was designed and synthesized. The chimeric peptide affinity to Ti disks, as well as its role in mediating MC3T3-E1 cell attachment and afterwards spreading on pre-coated Ti disks, was investigated. The chimeric peptide not only showed favorable affinity to Ti surfaces but also facilitated the adhesion of MC3T3-E1 cells.

引用

页码：191 / 197

页数：7

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