Identification of Novel AAV Capsid Variants with Enhanced Tropism for the Canine Outer Retina Following Intravitreal Delivery

被引:0
作者
Byrne, Leah C. [1 ]
Visel, Meike [2 ]
Dufour, Valerie [3 ]
Marinho, Felipe Pompeo [3 ]
Aguirre, Gustavo D. [3 ]
Beltran, William A. [3 ]
Flannery, John G. [2 ]
Schaffer, David V. [2 ]
机构
[1] Univ Calif Berkeley, Sch Vet Med, Dept Clin Studies, Helen Wills Neurosci Inst,Univ Penn, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
[3] Univ Penn, Sch Vet Med, Dept Clin Studies, Philadelphia, PA 19104 USA
关键词
D O I
10.1016/S1525-0016(16)33425-6
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
617
引用
收藏
页码:S244 / S245
页数:2
相关论文
共 48 条
[41]   A novel AAV capsid demonstrating high specificity to motor neurons with enhanced transduction in macaque and marmoset monkeys and mice following systemic administration [J].
Chatzi, C. ;
Dalwadi, D. ;
Huang, S. J. ;
Matsuzaki, Y. ;
Hirai, H. ;
Nakai, H. .
HUMAN GENE THERAPY, 2024, 35 (3-4) :A51-A51
[42]   An approach to identify novel Adeno-Associated Virus (AAV) capsids that provide enhanced retinal cell transduction following intravitreal injections [J].
Powers, John Michael ;
Adachi, Kei ;
Sivyer, Benjamin ;
Taylor, William Rowland ;
Pennesi, Mark E. ;
Nakai, Hiroyuki .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
[43]   Directed Evolution of an AAV9 Library Identifies a Capsid Variant with Enhanced Brain Tropism and Liver De-Targeting in Non-Human Primates and Mice Following Systemic Administration [J].
Moyer, Tyler ;
Graham, Kristin ;
Liu, Jiachen ;
Ren, Xiaoqin ;
Clement, Joseph ;
Bloedel, Alexis ;
Kulkarni, Anupriya ;
Looby, Kailyn ;
Khalid, Hamza ;
Amy, Bruce ;
Egbuchulam, Chiso ;
Laks, Dan ;
Child, Matthew ;
Kaur, Rupinderjit ;
Sayed-Zahid, Ambreen ;
Grannan, Michael ;
Chung, Charlotte ;
Knox, Tatiana ;
Hoffman, Brett ;
Kutchin, Alex ;
Johnson, Amy ;
Cameron, Andrew ;
Grant, Kyle ;
Yao, Johnny ;
Pande, Nilesh ;
Thompson, Jeff ;
Heffner, Garrett ;
Carter, Todd A. ;
Nonnenmacher, Mathieu E. .
MOLECULAR THERAPY, 2023, 31 (04) :57-57
[44]   In vivo screening of an adeno-associated virus capsid library in non-human primate eyes identifies a novel AAV variant with superior retinal penetration and transduction by intravitreal delivery [J].
Cepeda, D. ;
Keravala, A. ;
Nieves, J. ;
Aeran, R. ;
To, H. ;
Qureshi, T. Neal ;
Rosario, A. M. ;
Yeh, E. ;
Levinson, A. ;
Chavez, C. ;
Todorov, G. ;
Tai, A. ;
Gelfman, C. ;
Gasmi, M. .
HUMAN GENE THERAPY, 2019, 30 (11) :A20-A20
[45]   Stepwise Evolution of the AAV5-Derived Capsid VCAP-100 Identifies Novel Variants with Improved CNS Transduction and Liver Detargeting Following Systemic Injection [J].
Maura, Damien ;
Yu, Jennifer C. ;
Child, Matthew ;
Kaur, Roop ;
Thorpe, Zachary ;
Ren, Xiaoqin ;
Gebremedhin, Netsanet ;
Li, Jiangyu ;
Liu, Jiachen ;
Fiore, Timothy ;
Kavanagh, Dillon ;
Kubiak, Alexander ;
Grant, Kyle ;
Sayed-Zahid, Ambreen ;
Moyer, Tyler ;
Graham, Kristin P. ;
Kutchin, Alexander ;
Yao, Johnny ;
Carter, Todd A. ;
Nonnenmacher, Mathieu E. .
MOLECULAR THERAPY, 2023, 31 (04) :238-239
[46]   Bioinformatic Identification and Large-Scale In Vitro and In Vivo Characterization of Human-Derived Novel AAV2 and AAV2/3 Capsid Variants Reveals Vectors with New Biological Functions [J].
Luo, Li ;
Xu, Guangchao ;
Tai, Phillip W. L. ;
Qin, Wanru ;
Xiao, Yuanyuan ;
Wang, Chunmei ;
Ma, Hong ;
He, Ran ;
Su, Qin ;
Fong, Kaiyuen ;
Gong, Shoufang ;
Wei, Yuquan ;
Gao, Guangping .
MOLECULAR THERAPY, 2017, 25 (05) :231-231
[47]   Directed Evolution of AAV9 Peptide Display Libraries Identifies a Family of Cross-Species Variants with Enhanced Brain Tropism in Non-Human Primates and Mice Following Systemic Administration [J].
Moyer, Tyler ;
Li, Jiangyu ;
Laks, Dan R. ;
Child, Matthew A. ;
Tyson, Katherine ;
Kaur, Rupinderjit ;
Ren, Xiao-Qin ;
Sayed-Zahid, Ambreen ;
Grannon, Michael ;
Chung, Charlotte Hiu-Yan ;
Pande, Nilesh ;
Thompson, Jeff ;
Wang, Wei ;
Hasson, Samuel ;
Hefferan, Michael ;
Nonnenmacher, Mathieu .
MOLECULAR THERAPY, 2022, 30 (04) :556-557
[48]   CB 2679d-GT - A Novel Human Factor IX Variant Shows Enhanced Activity After Delivery Into Hemophilic Mice Using an AAV Capsid with High Liver Transduction [J].
Pekrun, Katja ;
Blouse, Grant E. ;
Zhang, Feijie ;
Le Moan, Natacha ;
Knudsen, Tom ;
Landau, Jeff ;
Kay, Mark A. .
MOLECULAR THERAPY, 2020, 28 (04) :172-173