NIR-II Responsive Hydrogel as an Angiogenesis Inhibition Agent for Tumor Microenvironment Reprogramming

被引:34
作者
Zhao, Senfeng [1 ]
Zhang, Ling [1 ]
Deng, Liu [1 ,2 ]
Ouyang, Jiang [1 ,3 ]
Xu, Qianqian [1 ,2 ]
Gao, Xinyu [1 ]
Zeng, Zhilin [1 ]
Liu, You-Nian [1 ,2 ]
机构
[1] Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China
[2] Cent South Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China
[3] Jinan Univ, Affiliated Hosp 1, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
anti-angiogenesis; cancer therapy; hydrogel; NIR-II responsive; WO2.9; nanosheet; CURRENT CHALLENGES; CANCER; THERAPY; RELEASE; CELLS; NO;
D O I
10.1002/smll.202103003
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Regulation of angiogenesis is a great challenge for effective anticancer therapy. Generally, anti-angiogenic therapies are focused on inhibition of inducers involved in pro-angiogenic communication pathways. Despite the great potential of anti-angiogenic therapy, engineering efficient angiogenesis inhibition agents (AIAs) is still a formidable challenge, since most anti-angiogenic therapies are limited due to the cancer recurrence via compensatory expression of different angiogenic mediators. Herein, we present a new strategy of near-infrared-II (NIR-II) responsive hydrogel AIAs, constructed by incorporation of nitric oxide (NO) precursor (BNN6) and 2D WO2.9 nanosheets within hydrogel (WB@hydrogel). Because of the defect/2D engineering, the bandgap of the WO2.9 nanosheets narrows, which extends the absorption to the NIR-II region. It offers a favorable NIR-II controlled manner for NO generation through irradiation time and light intensity. The continuous supply of NO can activate the expression of wild-type p53 protein and further reverse the transcriptional expression of pro- and anti-angiogenic factors of the tumor microenvironment (TME), subsequently alternating pro-angiogenic TME to anti-angiogenic TME. In the murine tumor model, this method achieved high tumor growth inhibition (TGI) rate and excellent anti-recurrence efficiency.
引用
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页数:11
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