The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

被引：25

作者：

Campbell, FM

Waterston, M

Andresen, LO

Sorensen, NS

Heegaard, PMH

Eckersall, PD

机构：

[1] Univ Glasgow, Fac Vet Med, Inst Comparat Med, Div Anim Prod & Publ Hlth, Glasgow G61 1QH, Lanark, Scotland

[2] Danish Inst Food & Vet Res, Dept Vet Diagnost & Res, DK-1790 Copenhagen, Denmark

来源：

VETERINARY RESEARCH | 2005年 / 36卷 / 04期

关键词：

acute phase proteins; pigs; infection Streptococcus suis;

D O I：

10.1051/vetres:2005017

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

引用

页码：657 / 664

页数：8

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