Remdesivir-associated bradycardia

被引:10
作者
Ching, Patrick R. [1 ]
Lee, Calvin [2 ]
机构
[1] Univ Maryland, Med Ctr, Dept Med, Midtown Campus, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Med, Div Cardiovasc Med, Baltimore, MD 21201 USA
关键词
cardiovascular medicine; COVID-19; infectious diseases; drugs and medicines;
D O I
10.1136/bcr-2021-245289
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Remdesivir is an antiviral used for the treatment of COVID-19 requiring hospitalisation. Information on its cardiovascular safety profile is scarce. We report the case of a 37-year-old man with COVID-19 who developed bradycardia after receiving remdesivir. We recommend a baseline ECG for all patients prior to receiving remdesivir and continuous cardiac monitoring during treatment, especially among those with underlying cardiovascular disease, elderly and using beta-blockers.
引用
收藏
页数:2
相关论文
共 10 条
  • [1] Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review
    Barkas, Fotios
    Styla, Chrysoula-Paraskevi
    Bechlioulis, Aris
    Milionis, Haralampos
    Liberopoulos, Evangelos
    [J]. JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE, 2021, 8 (02)
  • [2] Remdesivir for the Treatment of Covid-19-Final Report
    Beigel, John H.
    Tomashek, Kay M.
    Dodd, Lori E.
    Mehta, Aneesh K.
    Zingman, Barry S.
    Kalil, Andre C.
    Hohmann, Elizabeth
    Chu, Helen Y.
    Luetkemeyer, Annie
    Kline, Susan
    de Castilla, Diego Lopez
    Finberg, Robert W.
    Dierberg, Kerry
    Tapson, Victor
    Hsieh, Lanny
    Patterson, Thomas F.
    Paredes, Roger
    Sweeney, Daniel A.
    Short, William R.
    Touloumi, Giota
    Lye, David Chien
    Ohmagari, Norio
    Oh, Myoung-don
    Ruiz-Palacios, Guillermo M.
    Benfield, Thomas
    Faetkenheuer, Gerd
    Kortepeter, Mark G.
    Atmar, Robert L.
    Creech, C. Buddy
    Lundgren, Jens
    Babiker, Abdel G.
    Pett, Sarah
    Neaton, James D.
    Burgess, Timothy H.
    Bonnett, Tyler
    Green, Michelle
    Makowski, Mat
    Osinusi, Anu
    Nayak, Seema
    Lane, H. Clifford
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) : 1813 - 1826
  • [3] Bradycardia associated with remdesivir therapy for COVID-19 in a 59-year-old man
    Day, Leora Branfield
    Abdel-Qadir, Husam
    Fralick, Michael
    [J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 2021, 193 (17) : E612 - E615
  • [4] Safety profile of the antiviral drug remdesivir: An update
    Fan, Qianqian
    Zhang, Bo
    Ma, Jie
    Zhang, Shuyang
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2020, 130
  • [5] Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
    Gordon, Calvin J.
    Tchesnokov, Egor P.
    Woolner, Emma
    Perry, Jason K.
    Feng, Joy Y.
    Porter, Danielle P.
    Gotte, Matthias
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (20) : 6785 - 6797
  • [6] Compassionate Use of Remdesivir for Patients with Severe Covid-19
    Grein, J.
    Ohmagari, N.
    Shin, D.
    Diaz, G.
    Asperges, E.
    Castagna, A.
    Feldt, T.
    Green, G.
    Green, M. L.
    Lescure, F-X
    Nicastri, E.
    Oda, R.
    Yo, K.
    Quiros-Roldan, E.
    Studemeister, A.
    Redinski, J.
    Ahmed, S.
    Bernett, J.
    Chelliah, D.
    Chen, D.
    Chihara, S.
    Cohen, S. H.
    Cunningham, J.
    Monforte, A. DArminio
    Ismail, S.
    Kato, H.
    Lapadula, G.
    L'Her, E.
    Maeno, T.
    Majumder, S.
    Massari, M.
    Mora-Rillo, M.
    Mutoh, Y.
    Nguyen, D.
    Verweij, E.
    Zoufaly, A.
    Osinusi, A. O.
    DeZure, A.
    Zhao, Y.
    Zhong, L.
    Chokkalingam, A.
    Elboudwarej, E.
    Telep, L.
    Timbs, L.
    Henne, I
    Sellers, S.
    Cao, H.
    Tan, S. K.
    Winterbourne, L.
    Desai, P.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (24) : 2327 - 2336
  • [7] Gubitosa James C, 2020, JACC Case Rep, V2, P2260, DOI 10.1016/j.jaccas.2020.08.025
  • [8] Cardiac Adverse Events With Remdesivir in COVID-19 Infection
    Gupta, Anupam K.
    Parker, Barbara M.
    Priyadarshi, Vikash
    Parker, John
    [J]. CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (10)
  • [9] The Mechanism of the Negative Chronotropic and Dromotropic Actions of Adenosine 5′-triphosphate in the Heart: An Update
    Pelleg, Amir
    Belhassen, Bernard
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2010, 56 (01) : 106 - 109
  • [10] Serious bradycardia and remdesivir for coronavirus 2019 (COVID-19): a new safety concerns
    Touafchia, Anthony
    Bagheri, Haleh
    Carrie, Didier
    Durrieu, Genevieve
    Sommet, Agnes
    Chouchana, Laurent
    Montastruc, Francois
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2021, 27 (05) : 791.e5 - 791.e8