Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms

被引:6
作者
Mestrovic, Antonio [1 ]
Bozic, Josko [2 ]
Vukojevic, Katarina [3 ]
Tonkic, Ante [1 ,4 ]
机构
[1] Univ Hosp Split, Dept Gastroenterol, Split 21000, Croatia
[2] Univ Split, Sch Med, Dept Pathophysiol, Split 21000, Croatia
[3] Univ Split, Sch Med, Dept Anat, Split 21000, Croatia
[4] Univ Split, Sch Med, Dept Internal Med, Split 21000, Croatia
来源
MEDICINA-LITHUANIA | 2021年 / 57卷 / 08期
关键词
Helicobacter pylori; eradication therapy; quality of life; Gastrointestinal Symptom Rating Scale; hybrid therapy; concomitant therapy; QUALITY-OF-LIFE; FUNCTIONAL DYSPEPSIA; RATING-SCALE; INFECTION; PREVALENCE; IMPROVEMENT;
D O I
10.3390/medicina57080803
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: Helicobacter pylori (H. pylori) infection impairs quality of life. However, whether eradication therapy ameliorates gastrointestinal symptoms remains questionable. The main objective of this study was to evaluate the influence of H. pylori eradication therapy on gastrointestinal symptoms. Materials and Methods: A total of 140 patients, 59 women and 81 men, with a mean age of 61 and suffering from H. pylori infection in the University Hospital of Split, Croatia, were enrolled in the study. Patients were randomly assigned to either concomitant or hybrid therapies. The Gastrointestinal Symptom Rating Scale (GSRS) questionnaire was completed by patients prior to and after the eradication therapy. Results: In both groups, the total GSRS score improved significantly after therapy. In the concomitant group, the abdominal pain score, reflux symptoms score and indigestion score decreased significantly after therapy. In the group with hybrid therapy, all five groups of symptoms (abdominal pain, reflux symptoms, indigestion, diarrhea and constipation) significantly decreased after therapy. Patients with adverse events had significantly higher total GSRS scores after eradication therapy. Conclusions: H. pylori eradication therapy could alleviate gastrointestinal symptoms regardless of the treatment used, but the favorable effect seemed to be more pronounced after hybrid therapy.
引用
收藏
页数:7
相关论文
共 32 条
[1]   Changes in the prevalence of dyspepsia and Helicobacter pylori infection after 17 years:: The Sorreisa gastrointestinal disorder study [J].
Asfeldt, Anne Mette ;
Straume, Bjorn ;
Steigen, Sonja Eriksson ;
Lochen, Maja-Lisa ;
Florholmen, Jon ;
Bernersen, Bjorn ;
Johnsen, Roar ;
Paulssen, Eyvind J. .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2008, 23 (09) :625-633
[2]   Helicobacter pylori Virulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment [J].
Baj, Jacek ;
Forma, Alicja ;
Sitarz, Monika ;
Portincasa, Piero ;
Garruti, Gabriella ;
Krasowska, Danuta ;
Maciejewski, Ryszard .
CELLS, 2021, 10 (01) :1-37
[3]  
BUCKLEY M, 1995, ALIMENT PHARM THER, V9, P53
[4]   Effect of Helicobacter pylori Infection on Symptoms of Gastroenteritis Due to Enteropathogenic Escherichia coli in Adults [J].
Chang, Alicia Hsin-Ming ;
Haggerty, Thomas Dean ;
de Martel, Catherine ;
Leung, Cynthia Wai-Mun ;
Parsonnet, Julie .
DIGESTIVE DISEASES AND SCIENCES, 2011, 56 (02) :457-464
[5]   The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial [J].
Chen, Luyi ;
Xu, Wenli ;
Lee, Allen ;
He, Jiamin ;
Huang, Bixia ;
Zheng, Wenfang ;
Su, Tingting ;
Lai, Sanchuan ;
Long, Yanqin ;
Chu, Hua ;
Chen, Yujia ;
Wang, Lan ;
Wang, Kan ;
Si, Jianmin ;
Chen, Shujie .
EBIOMEDICINE, 2018, 35 :87-96
[6]  
CORREA P, 1992, CANCER RES, V52, P6735
[7]   WELL-BEING AND GASTROINTESTINAL SYMPTOMS AMONG PATIENTS REFERRED TO ENDOSCOPY OWING TO SUSPECTED DUODENAL-ULCER [J].
DIMENAS, E ;
GLISE, H ;
HALLERBACK, B ;
HERNQVIST, H ;
SVEDLUND, J ;
WIKLUND, I .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1995, 30 (11) :1046-1052
[8]   QUALITY-OF-LIFE IN PATIENTS WITH UPPER GASTROINTESTINAL SYMPTOMS - AN IMPROVED EVALUATION OF TREATMENT REGIMENS [J].
DIMENAS, E ;
GLISE, H ;
HALLERBACK, B ;
HERNQVIST, H ;
SVEDLUND, J ;
WIKLUND, I .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1993, 28 (08) :681-687
[9]   Relevance of norm values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease [J].
Dimenas, E ;
Carlsson, G ;
Glise, H ;
Israelsson, B ;
Wiklund, I .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1996, 31 :8-13
[10]   Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis [J].
Du, Li-Jun ;
Chen, Bin-Rui ;
Kim, John J. ;
Kim, Sarah ;
Shen, Jin-Hua ;
Dai, Ning .
WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (12) :3486-3495