Anti-Inflammatory Effects of 6,8-Diprenyl-7,4′-dihydroxyflavanone from Sophora tonkinensis on Lipopolysaccharide-Stimulated RAW 264.7 Cells

被引：18

作者：

Chae, Hee-Sung ^{[1
,2
]}

Yoo, Hunseung ^{[3
]}

Kim, Young-Mi ^{[1
,2
]}

Choi, Young Hee ^{[1
,2
]}

Lee, Chang Hoon ^{[1
,2
]}

Chin, Young-Won ^{[1
,2
]}

机构：

[1] Dongguk Univ Seoul, Coll Pharm, 32 Dongguk Lo, Goyang Si 410820, Gyeonggi Do, South Korea

[2] Dongguk Univ Seoul, Integrated Res Inst Drug Dev, 32 Dongguk Lo, Goyang Si 410820, Gyeonggi Do, South Korea

[3] SK Chem, New Drug Preclin & Analyt Team, Life Sci R&D Ctr, 310 Pangyo Ro, Songnam 463400, Gyeonggi Do, South Korea

来源：

MOLECULES | 2016年 / 21卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

6,8-diprenyl-7,4 '-dihydroxyflavanone; anti-inflammatory; nuclear factor-kappa B; extracellular signal-regulated kinases; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; GENE-EXPRESSION; NITRIC-OXIDE; IL-6; PRODUCTION; INFLAMMATION; MACROPHAGES; PATHWAYS; CONSTITUENTS; INHIBITION;

D O I：

10.3390/molecules21081049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anti-inflammatory e alpha ects and molecular mechanism of 6,8-diprenyl-7,4'-dihydroxyflavanone (DDF), one of the flavanones found in Sophora tonkinensis, were assessed in vitro through macrophage-mediated inflammation in the present study. The anti-inflammatory effects of DDF were not previously reported. DDF inhibited the production of nitric oxide and the expression of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6. Furthermore, the activation of nuclear factor-kappa B (NF-kappa B) and extracellular signal-regulated kinases (ERKs) in lipopolysaccharide-stimulated macrophages was suppressed by treatment with DDF. Therefore, DDF demonstrated potentially anti-inflammatory effects via the blockade of NF-kappa B and ERK activation in macrophages.

引用

页数：10

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