RU 486 reduces morphine-induced analgesia in mice, but steroid receptors are not involved

被引：2

作者：

Bianchi, M ^{[1
]}

Maggi, R ^{[1
]}

Panerai, AE ^{[1
]}

Martini, L ^{[1
]}

机构：

[1] UNIV MILAN,DEPT ENDOCRINOL,I-20129 MILAN,ITALY

来源：

PHARMACOLOGY | 1996年 / 52卷 / 06期

关键词：

analgesia; dexamethasone; test; hot plate; morphine; progesterone; RU; 486;

D O I：

10.1159/000139406

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of subcutaneous pretreatment with the glucocorticoid/progesterone receptor antagonist RU 486 on the antinociceptive action of peripherally administered morphine were evaluated by the hot-plate test in mice. The steroid significantly reduced the analgesic effect of the opiate. Neither dexamethasone nor progesterone modified the effects of RU 486 on morphine-induced analgesia. Therefore, the present data indicate that the modulatory effect of RU 486 on morphine-induced analgesia does not involve the binding of this drug to classical steroid receptors.

引用

页码：387 / 391

页数：5

共 18 条

[1] TREATMENT OF BREAST-CANCER WITH DIFFERENT ANTIPROGESTINS - PRECLINICAL AND CLINICAL-STUDIES [J].