Emerging Therapies for Nonalcoholic Fatty Liver Disease

被引：11

作者：

Hameed, Bilal ^{[1
]}

Terrault, Norah ^{[1
]}

机构：

[1] Univ Calif San Francisco, Div Gastroenterol, S357,513 Parnassus Ave, San Francisco, CA 94143 USA

来源：

CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 02期

关键词：

Nonalcoholic fatty liver disease; FXR agonists; Insulin sensitizers; PPAR agonists; Antifibrotic agents; FARNESOID-X-RECEPTOR; TISSUE INSULIN-RESISTANCE; LYSYL OXIDASE; REMOGLIFLOZIN ETABONATE; OBETICHOLIC ACID; NUCLEAR RECEPTOR; ADIPOSE-TISSUE; HEPATIC STEATOSIS; HUMAN HEPATOCYTES; GLYCEMIC CONTROL;

D O I：

10.1016/j.cld.2015.10.015

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic fatty liver disease is the most common cause of liver disease in the United States. There are no drug therapies approved for the treatment of nonalcoholic steatohepatitis (NASH). Multiple different pathways are involved in the pathogenesis and each can be the target of the therapy. It is possible that more than 1 target is involved in disease development and progression. Multiple clinical trials with promising agents are underway. Because NASH is a slowly progressive disease and treatment likely to be of prolonged duration, acceptance and approval of any agent will require information on long-term clinical benefits and safety.

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页码：365 / +

页数：22

相关论文

共 98 条

[21] A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR [J].

Downes, M ;

Verdecia, MA ;

Roecker, AJ ;

Hughes, R ;

Hogenesch, JB ;

Kast-Woelbern, HR ;

Bowman, ME ;

Ferrer, JL ;

Anisfeld, AM ;

Edwards, PA ;

Rosenfeld, JM ;

Alvarez, JGA ;

Noel, JP ;

Nicolaou, KC ;

Evans, RM .

MOLECULAR CELL, 2003, 11 (04) :1079-1092

[22] Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits [J].

Drucker, Daniel J. ;

Sherman, Steven I. ;

Gorelick, Fred S. ;

Bergenstal, Richard M. ;

Sherwin, Robert S. ;

Buse, John B. .

DIABETES CARE, 2010, 33 (02) :428-433

[23] Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease [J].

Fabbrini, Elisa ;

Mohammed, B. Selma ;

Magkos, Faidon ;

Korenblat, Kevin M. ;

Patterson, Bruce W. ;

Klein, Samuel .

GASTROENTEROLOGY, 2008, 134 (02) :424-431

[24] Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance [J].

Fang, Sungsoon ;

Suh, Jae Myoung ;

Reilly, Shannon M. ;

Yu, Elizabeth ;

Osborn, Olivia ;

Lackey, Denise ;

Yoshihara, Eiji ;

Perino, Alessia ;

Jacinto, Sandra ;

Lukasheva, Yelizaveta ;

Atkins, Annette R. ;

Khvat, Alexander ;

Schnab, Bernd ;

Yu, Ruth T. ;

Brenner, David A. ;

Coulter, Sally ;

Liddle, Christopher ;

Schoonjans, Kristina ;

Olefsky, Jerrold M. ;

Saltiel, Alan R. ;

Downes, Michael ;

Evans, Ronald M. .

NATURE MEDICINE, 2015, 21 (02) :159-165

[25] IDENTIFICATION OF A NUCLEAR RECEPTOR THAT IS ACTIVATED BY FARNESOL METABOLITES [J].

FORMAN, BM ;

GOODE, E ;

CHEN, J ;

ORO, AE ;

BRADLEY, DJ ;

PERLMANN, T ;

NOONAN, DJ ;

BURKA, LT ;

MCMORRIS, T ;

LAMPH, WW ;

EVANS, RM ;

WEINBERGER, C .

CELL, 1995, 81 (05) :687-693

[26] Importance of Changes in Adipose Tissue Insulin Resistance to Histological Response During Thiazolidinedione Treatment of Patients with Nonalcoholic Steatohepatitis [J].

Gastaldelli, Amalia ;

Harrison, Stephen A. ;

Belfort-Aguilar, Renata ;

Hardies, Lou Jean ;

Balas, Bogdan ;

Schenker, Steven ;

Cusi, Kenneth .

HEPATOLOGY, 2009, 50 (04) :1087-1093

[27] Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis [J].

Georgescu, Eugen Florin ;

Ionescu, Reanina ;

Niculescu, Mihaela ;

Mogoanta, Laurentiu ;

Vancica, Liliana .

WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (08) :942-954

[28] Angiotensin receptor blockers in the treatment of NASH/NAFLD: Could they be a first-class option? [J].

Georgescu, Eugen Florin .

ADVANCES IN THERAPY, 2008, 25 (11) :1141-1174

[29] Glucagon-Like Peptide-1 Receptor Is Present on Human Hepatocytes and Has a Direct Role in Decreasing Hepatic Steatosis In Vitro by Modulating Elements of the Insulin Signaling Pathway [J].

Gupta, Nitika Arora ;

Mells, Jamie ;

Dunham, Richard M. ;

Grakoui, Arash ;

Handy, Jeffrey ;

Saxena, Neeraj Kumar ;

Anania, Frank A. .

HEPATOLOGY, 2010, 51 (05) :1584-1592

[30]

Harrison SA, 2014, HEPATOLOGY, V60, p225A

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