Desmosomes in Human Disease

被引：51
|
作者：
Najor, Nicole A. [1 ]
机构：
[1] Univ Detroit Mercy, Dept Biol, Detroit, MI 48221 USA
来源：
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13 | 2018年 / 13卷
关键词：
desmosomal cadherins; armadillo proteins; plakin proteins; desmosomal diseases; AUTOSOMAL RECESSIVE HYPOTRICHOSIS; PEMPHIGUS-VULGARIS ANTIGEN; RIGHT-VENTRICULAR CARDIOMYOPATHY; RECURRENT INTRAGENIC DELETION; E-CADHERIN EXPRESSION; AMINO-ACID-SEQUENCE; PALMOPLANTAR KERATODERMA; DESMOGLEIN-4; GENE; SKIN FRAGILITY; WOOLLY HAIR;
D O I：
10.1146/annurev-pathol-020117-044030
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.
引用
收藏
页码：51 / 70
页数：20
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