Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2′-deoxyuridines

被引：34

作者：

Krim, Jamal ^{[1
,2
]}

Gruenewald, Christian ^{[1
]}

Taourirte, Moha ^{[2
]}

Engels, Joachim W. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany

[2] Fac Sci & Tech Gueliz, Lab Chim Bioorgan & Macromol, Marrakech 40000, Morocco

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 01期

关键词：

Microwave-assisted; Fluorescence; Benzimidazole; Antibacterial; PROTON-TRANSFER; DNA; ANALOGS; BENZIMIDAZOLES; NUCLEOSIDES; POTENT; BINDING; OLIGODEOXYNUCLEOTIDES; OLIGONUCLEOTIDES; TAUTOMERISM;

D O I：

10.1016/j.bmc.2011.10.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel C-5 benzimidazolyl-2'-deoxyuridines was synthesized in good yields under solvent-free conditions and microwave irradiation from 5-formyl-2'-deoxyuridine and arylenediamine derivatives in the presence of NaHSO3 as catalyst. Their absorption and fluorescence spectra were measured. They showed intense fluorescence around 400-500 nm with quantum yields between 0.3 and 0.5. All compounds studied in this work were screened for their antibacterial activities against a series of Gram positive and negative bacteria. The trifluoromethyl substituted benzimidazole derivatives showed some antibacterial activity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：480 / 486

页数：7

共 45 条

[1] New Uracil Dimers Showing Erythroid Differentiation Inducing Activities [J].