Subjective global assessment and prealbumin levels of esophageal cancer patients undergoing concurrent chemoradiotherapy

被引:25
作者
Pan, Peng [1 ,2 ]
Tao, Guangzhou [2 ]
Sun, XinChen [1 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Radiotherapy, Nanjing, Jiangsu, Peoples R China
关键词
Malnutrition; Nutrition assessment; Subjective global assessment; chemoradiotherapy; prealbumin; NUTRITIONAL SUPPORT; WEIGHT-LOSS; RADIOTHERAPY; ASSOCIATION; TOXICITY; ISSUES;
D O I
10.3305/nh.2015.31.5.8596
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Aims: To evaluate the nutritional status of patients undergoing chemoradiotherapy for esophageal cancer using subjective global assessment (SGA) and association of prealbumin levels to nutritional status. Methods: A prospective study was performed on 154 patients with esophageal cancer who were treated with concurrent chemoradiotherapy at center of radiation oncology in Huai'an First People's Hospital from January 2012 to May 2013. The patients' nutritional status after receiving concurrent chemoradiotherapy were evaluated using SGA tool. Serum total protein, prealbumin, albumin and other biochemical nutrition parameters including triglyceride, total cholesterol, cholesterol and glucose were determined before beginning and after the end of radiotherapy. Results: Malnutrition developed in 129 (83.8%) patients. According to SGA results, 16.2%, 66.2%, and17.6% of patients were classified as A, B, or C, respectively. Loss of subcutaneous fat or muscle wasting (odds ratio [OR] 11.522); increased metabolic demand/stress (OR 8.637); ankle, sacral edema, or ascites (OR 3.229) and weight loss >= 5% (OR 2.294) were significantly associated with malnutrition (SGA B or C; p < 0.001). Prealbumin level after the end of radiotherapy was significantly lower in patients with malnutrition (17 +/- 5 g/dl vs. 21 +/- 5 g/dl, p = 0.005), but it showed no difference before beginning radiotherapy (24 +/- 4 g/dl vs. 22 +/- 5 g/dl, p > 0.05). On the other hand, there was no significant difference in term of other nutrition parameters whether before beginning or after the end of radiotherapy (p > 0.05). Conclusions: The prevalence of malnutrition was high in esophageal cancer patients undergoing concurrent chemoradiotherapy. The results serve as a basis for implementation of nutrition intervention to patients being treated at radiotherapy departments. Prealbumin showed relation with SGA rating and should be considered as a sensitive nutritional biomarker for evaluating nutritional status of esophageal cancer patients undergoing concurrent chemoradiotherapy.
引用
收藏
页码:2167 / 2173
页数:7
相关论文
共 16 条
[1]   Association of nutritional status and serum albumin levels with development of toxicity in patients with advanced non-small cell lung cancer treated with paclitaxel-cisplatin chemotherapy: a prospective study [J].
Arrieta, Oscar ;
Michel Ortega, Rosa M. ;
Villanueva-Rodriguez, Geraldine ;
Serna-Thome, Maria G. ;
Flores-Estrada, Diana ;
Diaz-Romero, Consuelo ;
Rodriguez, Cindy M. ;
Martinez, Luis ;
Sanchez-Lara, Karla .
BMC CANCER, 2010, 10
[2]   A prospective analysis of factors that influence weight loss in patients undergoing radiotherapy [J].
Cacicedo, Jon ;
Casquero, Francisco ;
Martinez-Indart, Lorea ;
del Hoyo, Olga ;
Gomez de Iturriaga, Alfonso ;
Navarro, Arturo ;
Bilbao, Pedro .
CHINESE JOURNAL OF CANCER, 2014, 33 (04) :204-210
[3]   Detection of risk factors that influence weight loss in patients undergoing radiotherapy [J].
Cacicedo, Jon ;
Casquero, Francisco ;
Martinez-Indart, Lorea ;
del Hoyo, Olga ;
Gomez de Iturriaga, Alfonso ;
Muruzabal, Irma ;
Carvajal, Claudia ;
Boveda, Elsira ;
Ruiz, Blanca ;
Loayza, Armando ;
Usategui, Begona ;
Lasso, Aurora ;
Hortelano, Eduardo ;
Bilbao, Pedro .
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 2012, 17 (05) :269-275
[4]   Cancer: Impact of nutrition intervention outcome - Nutrition issues for patients [J].
Capra, S ;
Ferguson, M ;
Ried, K .
NUTRITION, 2001, 17 (09) :769-772
[5]   TOXICITY CRITERIA OF THE RADIATION-THERAPY ONCOLOGY GROUP (RTOG) AND THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER (EORTC) [J].
COX, JD ;
STETZ, J ;
PAJAK, TF .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 31 (05) :1341-1346
[6]   MALNUTRITION IN PATIENTS WITH CANCER; FOUR YEARS EXPERIENCE [J].
Fernandez Lopez, Maria Teresa ;
Saenz Fernandez, Cecilia Alejandra ;
de Sas Prada, Maria Trinidad ;
Alonso Urrutia, Susana ;
Bardasco Alonso, Maria Luisa ;
Alves Perez, Maria Teresa ;
Rivero Luis, Maria Teresa ;
Alvarez Vazquez, Paula ;
Mato Mato, Jose Antonio .
NUTRICION HOSPITALARIA, 2013, 28 (02) :372-381
[7]   Nutritional assessment using prealbumin as an objective criterion to determine whom should not undergo primary radical cytoreductive surgery for ovarian cancer [J].
Geisler, John P. ;
Linnemeier, Georgiann C. ;
Thomas, Amanda J. ;
Manahan, Kelly J. .
GYNECOLOGIC ONCOLOGY, 2007, 106 (01) :128-131
[8]  
Gudny Geirsdottir O, 2008, FOOD NUTR RES, V52, P477
[9]  
Guerra LT, 2009, NUTR HOSP, V24, P241
[10]   Clinical Determinants of Weight Loss in Patients with Esophageal Carcinoma During Radiotherapy: a Prospective Longitudinal View [J].
Jiang, Nan ;
Zhao, Jin-Zhi ;
Chen, Xiao-Cen ;
Li, Li-Ya ;
Zhang, Li-Juan ;
Zhao, Yue .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (05) :1943-1948