In vitro modeling of central nervous system myelination and remyelination

被引：53

作者：

Jarjour, Andrew A. ^{[1
]}

Zhang, Hui ^{[1
]}

Bauer, Nina ^{[1
]}

Ffrench-Constant, Charles ^{[1
]}

Williams, Anna ^{[1
]}

机构：

[1] Queens Med Res Ctr, MRC Ctr Regenerat Med, Edinburgh MS Ctr, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

GLIA | 2012年 / 60卷 / 01期

基金：

英国惠康基金;

关键词：

oligodendrocyte; culture; organotypic slice; myelin; BRAIN-CELL-CULTURES; ELECTRON MICROSCOPIC OBSERVATIONS; EMBRYONIC SPINAL-CORD; ROOT GANGLION NEURONS; TISSUE-CULTURE; CNS REMYELINATION; MOUSE CEREBELLUM; PRECURSOR CELLS; SLICE CULTURES; FETAL MOUSE;

D O I：

10.1002/glia.21231

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review aims to summarize the current techniques to study myelination and remyelination in culture systems. We attempt to put these into historical context, and to identify the strengths and weaknesses of each approach, which vary depending on the experimental question to be tested. We discuss the difficulty and importance of quantification of myelination and in particular remyelination. Finally, we provide our predictions of how these techniques will and should develop in the future. (c) 2011 Wiley Periodicals, Inc.

引用

页码：1 / 12

页数：12

共 103 条

[1] A single intracerebral microinjection of platelet-derived growth factor (PDGF) accelerates the rate of remyelination in vivo [J].