In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter

被引：48

作者：

Wang, Dou ^{[1
,2
]}

Ge, Chenchen ^{[1
,3
]}

Liang, Weiyuan ^{[4
,5
]}

Yang, Qinhe ^{[6
]}

Liu, Quan ^{[1
,3
]}

Ma, Wei ^{[1
]}

Shi, Lulin ^{[1
]}

Wu, Hong ^{[1
]}

Zhang, Yuhua ^{[1
]}

Wu, Zongze ^{[1
]}

Wei, Chaoying ^{[1
]}

Huang, Luodan ^{[1
]}

Fang, Zhiyuan ^{[7
]}

Liu, Liping ^{[1
]}

Bao, Shiyun ^{[1
]}

Zhang, Han ^{[4
,5
]}

机构：

[1] Jinan Univ, Shenzhen Peoples Hosp, Dept Hepatobiliary & Pancreat Surg, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China

[2] Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

[3] Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Guangdong, Peoples R China

[4] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518060, Guangdong, Peoples R China

[5] Shenzhen Univ, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Shenzhen 518060, Guangdong, Peoples R China

[6] Jinan Univ, Sch Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China

[7] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

ADVANCED SCIENCE | 2020年 / 7卷 / 17期

关键词：

black phosphorus; circulating tumor cells; EpCAM; intravenous catheters; photothermal therapy; PERIPHERAL-BLOOD; CANCER-PATIENTS; THERAPY; LIGHT; CLUSTERS; CAPTURE;

D O I：

10.1002/advs.202000940

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The circulating tumor cell (CTC) count is closely related to cancer recurrence and metastasis. The technology that can in vivo destroy CTCs may bring great benefits to patients, which is an urgent clinical demand. Here, a minimally invasive therapeutic intravenous catheter for in vivo enriching and photothermal killing of CTCs is developed. The surface of catheter is modified with anti-EpCAM antibody and the interior is filled with black phosphorus nanosheets (BPNSs). CTCs in the peripheral blood are captured by the catheter continually with the aid of circulation. The captured CTCs are used for downstream analyses or in vivo eliminated by the near-infrared (NIR) photothermal effect of BPNSs. A capture efficiency of 2.1% is obtained during the 5 min of treatment, and 100% of the captured CTCs are killed by following NIR light irradiation in both an in vitro closed-loop circulation system and an in vivo rabbit model. This cost-effective modality for lowering the CTCs burden can be a good supplement to traditional therapies, which holds great promise as an effective clinical intervention for cancer patients.

引用

页数：9

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