AIE-active florescent polymers: The design, synthesis and the cell imaging application

被引：11

作者：

Lei, Lei ^{[1
]}

Ma, Hengchang ^{[1
]}

Qin, Yanfang ^{[1
]}

Yang, Manyi ^{[1
]}

Ma, Yucheng ^{[1
]}

Wang, Tao ^{[1
]}

Yang, Yuan ^{[1
]}

Lei, Ziqiang ^{[1
]}

Lu, Dedai ^{[1
]}

Guan, Xiaolin ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Ecoenvironm Related Polymer Mat, Key Lab Polymer Mat,Minist Gansu Prov,Minist Educ, Lanzhou 730070, Gansu, Peoples R China

来源：

POLYMER | 2017年 / 133卷

基金：

中国国家自然科学基金;

关键词：

PAA; pH-responsive; AIE; Cell imaging; POLY(ETHYLENE GLYCOL); FLUORESCENT PROTEINS; MAGNETIC-RESONANCE; RECENT PROGRESS; NANOPARTICLES; COPOLYMERS; PROBES; PH; BIOPROBE; RELEASE;

D O I：

10.1016/j.polymer.2017.11.030

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Fluorescence imaging, especially specific organelle imaging, has become a significant technology to comprehending cell transplantation, migration, division, fusion, and lysis. In this paper, we designed and synthesized a water soluble and fluorescent polymer named as Poly(AA-TPA-d), which was pH-responsive by the fluorescence channel due to the presence of poly acrylic acid as the polymer backbone. The research results demonstrated that Poly(AA-TPA-d) exhibits novel aggregation-inducedemission (AIE) property. Additionally, due to the hydrogen bond formation and C=O center dot center dot center dot pi interactions between methyl acrylate groups, Poly(AA-TPA-d) was of excellent hydrogel formation ability. Moreover, Poly(AA-TPA-d) displayed good bio-compatibility with the living MPC5 cells and highly specific cytoplasm-targeting ability by MTT assay and cell staining experiment respectively. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：151 / 159

页数：9

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