The dual role of the X-linked FoxP3 gene in human cancers

被引：27
|
作者：
Redpath, Margaret [1 ]
Xu, Bin [1 ]
van Kempen, Leon C. [1 ,2 ]
Spatz, Alan [1 ,2 ]
机构：
[1] McGill Univ, Dept Pathol, Montreal, PQ, Canada
[2] Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada
来源：
MOLECULAR ONCOLOGY | 2011年 / 5卷 / 02期
关键词：
Melanoma; Fox3P; T-lymphocyte-associated antigen 4; (CTLA-4)/ipilimumab; REGULATORY T-CELLS; TRANSCRIPTION FACTOR FOXP3; ROR-GAMMA-T; TGF-BETA; BREAST-CANCER; CUTTING EDGE; EPIGENETIC REGULATION; LUPUS-ERYTHEMATOSUS; SPLICE VARIANTS; EXPRESSION;
D O I：
10.1016/j.molonc.2011.03.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The FoxP3 (forkhead box P3) gene is an X-linked gene that is submitted to inactivation. It is an essential transcription factor in CD4(+)CD25(+)FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. Moreover, FoxP3 is an important tumor suppressor gene in carcinomas and has putative cancer suppressor gene function in cutaneous melanoma as well. Therefore understanding the structure and function of the FoxP3 gene is crucial to gaining insight into the biology of melanoma to better develop immunotherapeutics and future therapeutic strategies. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：156 / 163
页数：8
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