Metabolic control of B cells: more questions than answers

被引：10

作者：

Capasso, Melania ^{[1
]}

Alyahyawl, Alaa Rashed ^{[1
]}

Spear, Sarah ^{[1
]}

机构：

[1] Queen Mary Univ London, Ctr Canc & Inflammat, Barts Canc Inst, London, England

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

基金：

英国医学研究理事会;

关键词：

B lymphocytes; obesity and inflammation; insulin resistance; B regulatory cells; inflammatory cytokines; ADIPOSE-TISSUE; INSULIN-RESISTANCE; T-CELLS; OBESITY; INFLAMMATION; LYMPHOCYTES; REGULATORS;

D O I：

10.3389/fimmu.2015.00080

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is now accepted that metabolic disorders such as type 2 diabetes (T2D) and obesity are characterized by alterations in immune cells. Indeed, immune cells have been shown to play a critical role in fueling the inflammation that accompanies increased fat deposition and insulin resistance. Both the innate (macrophages) and the adaptive arm (CD4 and CD8 T cells, in particular) significantly contribute to the chronic inflammatory state that characterizes these conditions. B cells, however, have until recently remained significantly understudied. This is not due to the fact that they do not play as significant a role, as more recent publications appear to show. Here, we briefly review the most recent literature and highlight the remaining outstanding questions. © 2015 Capasso, Rashed Alyahyawi and Spear.

引用

页数：4

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